Amphiphilic pentaazamacrocyclic manganese superoxide dismutase mimetics

Journal article
(Original article)


Publication Details

Author(s): Lieb D, Kenkel I, Miljkovic J, Moldenhauer D, Weber N, Filipovic M, Gröhn F, Ivanovic-Burmazovic I
Journal: Inorganic Chemistry
Publisher: American Chemical Society
Publication year: 2014
Volume: 53
Journal issue: 2
Pages range: 1009-1020
ISSN: 0020-1669
eISSN: 1520-510X


Abstract


Five newly functionalized pentaazamacrocyclic manganese complexes, with variable lengths and amounts of the aliphatic groups (three compounds with one linear chain containing 12, 16, and 22 carbon atoms, i.e., MnL1, MnL2, and MnL3, respectively, as well as two compounds containing two C12 and C16 chains, MnL4 and MnL5, respectively) that are derivatives of the known SOD mimetic, Mn(Me-Pyane), have been synthesized. These amphiphilic complexes were characterized by the ESI mass spectrometry, potentiometric titrations, light scattering, cyclic voltammetry, and direct stopped-flow determination of their SOD activity at pH 8.1 and 7.4 (in phosphate and HEPES buffers). The formation of supramolecular aggregates that predominantly exist in the solution as a defined micellar/nanostructure assembly, with an average 400 nm size, has been demonstrated for MnL1. The biological effects of the selected complexes (MnL1 and MnL2) on the superoxide level in cytosol and mitochondria have been tested, as well as their effects on the prevention of the lipid peroxidation induced by paraquat. Advantages and disadvantages of the lipophilic pentaazamacrocyclic manganese SOD mimetics in comparison to the corresponding nonsubstituted SOD active complex have been discussed. © 2013 American Chemical Society.



FAU Authors / FAU Editors

Filipovic, Milos
Lehrstuhl für Bioanorganische Chemie
Gröhn, Franziska Prof. Dr.
Professur für Molekulare Nanostrukturen
Ivanovic-Burmazovic, Ivana Prof. Dr.
Lehrstuhl für Bioanorganische Chemie
Kenkel, Isabell
Lehrstuhl für Bioanorganische Chemie
Lieb, Dominik Dr.
Lehrstuhl für Bioanorganische Chemie
Miljkovic, Jan
Lehrstuhl für Bioanorganische Chemie
Moldenhauer, Daniel
Professur für Molekulare Nanostrukturen
Weber, Nadine
Lehrstuhl für Bioanorganische Chemie


How to cite

APA:
Lieb, D., Kenkel, I., Miljkovic, J., Moldenhauer, D., Weber, N., Filipovic, M.,... Ivanovic-Burmazovic, I. (2014). Amphiphilic pentaazamacrocyclic manganese superoxide dismutase mimetics. Inorganic Chemistry, 53(2), 1009-1020. https://dx.doi.org/10.1021/ic402469t

MLA:
Lieb, Dominik, et al. "Amphiphilic pentaazamacrocyclic manganese superoxide dismutase mimetics." Inorganic Chemistry 53.2 (2014): 1009-1020.

BibTeX: 

Last updated on 2019-19-08 at 13:07