Receptors, cells and circuits involved in pruritus of systemic disorders
Kremer AE, Feramisco J, Reeh P, Beuers U, Elferink RRIO (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 1842
Pages Range: 869-92
Journal Issue: 7
DOI: 10.1016/j.bbadis.2014.02.007
Abstract
Pruritus is a sensory phenomenon accompanying a broad range of systemic disorders including hematologic and lymphoproliferative disorders, metabolic and endocrine diseases, solid tumours, and infectious diseases. The molecular mechanisms involved in itch sensation remain enigmatic in most of these diseases. However, from studies in patients and animal models a large number of mediators and receptors responsible for scratching behaviour have been identified in recent years. New insights into the interplay between neuronal and non-neuronal cells in the initiation, modulation and sensitization of itch sensation have been acquired. This review highlights the current knowledge of the molecular mechanism involved in pruritus of systemic disorders and summarizes the signalling pathways of biogenic amines, neuropeptides, proteases, eicosanoids, cytokines, opioids, endocannabinoids, neurotrophins, phospholipids and other signalling molecules participating in pruritus.
Authors with CRIS profile
Involved external institutions
University of Amsterdam
Netherlands (NL)
University of California San Francisco (UCSF)
United States (USA) (US)
Netherlands (NL)
University of California San Francisco (UCSF)
United States (USA) (US)
How to cite
APA:
Kremer, A.E., Feramisco, J., Reeh, P., Beuers, U., & Elferink, R.R.I.O. (2014). Receptors, cells and circuits involved in pruritus of systemic disorders. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1842(7), 869-92. https://doi.org/10.1016/j.bbadis.2014.02.007
MLA:
Kremer, Andreas E., et al. "Receptors, cells and circuits involved in pruritus of systemic disorders." Biochimica et Biophysica Acta - Molecular Basis of Disease 1842.7 (2014): 869-92.
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