Membrane phase transition during heating and cooling: molecular insight into reversible melting.

Journal article
(Original article)


Publication Details

Author(s): Sun L, Böckmann R
Journal: European biophysics journal : EBJ
Publication year: 2017
ISSN: 1432-1017
Language: English


Abstract


With increasing temperature, lipid bilayers undergo a gel-fluid phase transition, which plays an essential role in many physiological phenomena. In the present work, this first-order phase transition was investigated for variable heating and cooling rates for a dipalmitoylphosphatidylcholine (DPPC) lipid bilayer by means of atomistic molecular dynamics simulations. Alternative methods to track the melting temperature [Formula: see text] are compared. The resulting [Formula: see text] is shown to be independent of the scan rate for small heating rates (0.05-0.3 K/ns) implying reversible melting, and increases for larger heating (0.3-4 K/ns) or cooling rates (2-0.1 K/ns). The reported dependency of the melting temperature on the heating rate is in perfect agreement with a two-state kinetic rate model as suggested previously. Expansion and shrinkage, as well as the dynamics of melting seeds is described. The simulations further exhibit a relative shift between melting seeds in opposing membrane leaflets as predicted from continuum elastic theory.



FAU Authors / FAU Editors

Böckmann, Rainer Prof. Dr.
Professur für Computational Biology
Sun, Liping
Professur für Computational Biology


Additional Organisation
Professur für Computational Biology
Graduiertenkolleg 1962 Dynamische Wechselwirkungen an Biologischen Membranen - von Einzelmolekülen zum Gewebe


How to cite

APA:
Sun, L., & Böckmann, R. (2017). Membrane phase transition during heating and cooling: molecular insight into reversible melting. European biophysics journal : EBJ. https://dx.doi.org/10.1007/s00249-017-1237-3

MLA:
Sun, Liping, and Rainer Böckmann. "Membrane phase transition during heating and cooling: molecular insight into reversible melting." European biophysics journal : EBJ (2017).

BibTeX: 

Last updated on 2018-16-10 at 00:10