Antibacterial Effect of a 4x Cu-TiO2 Coating Simulating Acute Periprosthetic Infection-An Animal Model

Journal article


Publication Details

Author(s): Mauerer A, Stenglein S, Schulz-Drost S, Schoerner C, Taylor D, Krinner S, Heidenau F, Adler W, Forst R
Journal: Molecules
Publication year: 2017
Volume: 22
Journal issue: 7
ISSN: 1420-3049


Abstract


The purpose of our study was to investigate the antibacterial effect of a spacer (Ti6Al4V) coated with 4x Cu-TiO? in an animal model simulating an acute periprosthetic infection by Staphylococcus aureus. Ti6Al4 bolts contaminated with Staphylococcus aureus were implanted into the femoral condyle of rabbits (n = 36) divided into 3 groups. After one week in group 1 (control) the bolts were removed without any replacement. In group2 Ti6Al4V bolts with a 4x Cu-TiO? coating and in group 3 beads of a gentamicin-PMMA chain were imbedded into the borehole. Microbiological investigation was performed at the primary surgery, at the revision surgery and after scarification of the rabbits 3 weeks after the first surgery. Blood tests were conducted weekly. The initial overall infection rate was 88.9%. In group 2 and 3 a significant decrease of the infection rate was shown in contrast to the control group. The C-reactive protein (CRP) levels declined one week after the first surgery except in the control group where the CRP level even increased. This is the first in vivo study that demonstrated the antibacterial effects of a fourfold Cu-TiO? coating. For the future, the coating investigated could be a promising option in the treatment of implant-associated infections.



FAU Authors / FAU Editors

Adler, Werner PD Dr.
Lehrstuhl für Biometrie und Epidemiologie
Forst, Raimund Prof. Dr. med.
Lehrstuhl für Orthopädie mit Orthopädischer Chirurgie
Schulz-Drost, Stefan PD Dr.
Medizinische Fakultät


External institutions
BioCer Entwicklungs-GmbH
Sana Kliniken AG
St. Theresien-Krankenhaus Nürnberg


How to cite

APA:
Mauerer, A., Stenglein, S., Schulz-Drost, S., Schoerner, C., Taylor, D., Krinner, S.,... Forst, R. (2017). Antibacterial Effect of a 4x Cu-TiO2 Coating Simulating Acute Periprosthetic Infection-An Animal Model. Molecules, 22(7). https://dx.doi.org/10.3390/molecules22071042

MLA:
Mauerer, Andreas, et al. "Antibacterial Effect of a 4x Cu-TiO2 Coating Simulating Acute Periprosthetic Infection-An Animal Model." Molecules 22.7 (2017).

BibTeX: 

Last updated on 2018-09-10 at 02:17