The role of the miR-148/-152 family in physiology and disease

Friedrich M, Pracht K, Mashreghi MF, Jäck HM, Radbruch A, Seliger B (2017)

Publication Type: Journal article

Publication year: 2017

Journal

European Journal of Immunology Wiley-VCH Verlag

Book Volume: 47

Pages Range: 2026-2038

Journal Issue: 12

DOI: 10.1002/eji.201747132

Abstract

MicroRNAs (miRNAs) are endogenously encoded ~22 nt small non-coding RNAs. They function as key players of many cellular processes by base pairing with target mRNAs and thereby impairing gene expression at the post-transcriptional level. Recent findings demonstrate a critical role of many miRNAs in immune cell differentiation and immune responses, which is also associated with the development and progression of many tumor and non-tumor diseases. Here we review the multifaceted miRNA-148/-152 family members consisting of miR-148a, miR-148b and miR-152. Next to regulation mechanisms that control the expression of this miRNA family, we will focus on (i) the role of miR-148a in regulating B and T lymphocyte function and its role in associated diseases and (ii) the importance of miR-148/-152 family members for cancer initiation, tumor growth and metastasis formation. In addition, this review aims to highlight some selected targets of the miRNA-148/-152 family members, which are involved in the biology of cancer and maintenance of epigenetic patterns. In conclusion, members of the miR-148/-152 family might represent prognostic markers and/or potential therapeutic targets for treatment of autoimmune disorders, chronic inflammatory diseases and multiple types of cancer.

Authors with CRIS profile

Katharina Pracht Professur für Immunologie Hans-Martin Jäck Department of Molecular Immunology

Involved external institutions

Martin-Luther-Universität Halle-Wittenberg (MLU) DE Germany (DE) Deutsches Rheuma-Forschungszentrum (DRFZ) DE Germany (DE)

How to cite

APA:

Friedrich, M., Pracht, K., Mashreghi, M.-F., Jäck, H.-M., Radbruch, A., & Seliger, B. (2017). The role of the miR-148/-152 family in physiology and disease. European Journal of Immunology, 47(12), 2026-2038. https://dx.doi.org/10.1002/eji.201747132

MLA:

Friedrich, Michael, et al. "The role of the miR-148/-152 family in physiology and disease." European Journal of Immunology 47.12 (2017): 2026-2038.

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