EMT in cancer

Journal article

Publication Details

Author(s): Brabletz T, Kalluri R, Nieto MA, Weinberg RA
Journal: Nature Reviews Cancer
Publication year: 2018
Volume: 18
Journal issue: 2
Pages range: 128-134
ISSN: 1474-175X


Similar to embryonic development, changes in cell phenotypes defined as an epithelial to mesenchymal transition (EMT) have been shown to play a role in the tumorigenic process. Although the first description of EMT in cancer was in cell cultures, evidence for its role in vivo is now widely reported but also actively debated. Moreover, current research has exemplified just how complex this phenomenon is in cancer, leaving many exciting, open questions for researchers to answer in the future. With these points in mind, we asked four scientists for their opinions on the role of EMT in cancer and the challenges faced by scientists working in this fast-moving field.

FAU Authors / FAU Editors

Brabletz, Thomas Prof. Dr. med.
Lehrstuhl für Experimentelle Medizin mit dem Schwerpunkt Molekulare Pathogeneseforschung

External institutions with authors

Instituto de Neurociencias (IN)
Massachusetts Institute of Technology (MIT)
University of Texas MD Anderson Cancer Center

How to cite

Brabletz, T., Kalluri, R., Nieto, M.A., & Weinberg, R.A. (2018). EMT in cancer. Nature Reviews Cancer, 18(2), 128-134. https://dx.doi.org/10.1038/nrc.2017.118

Brabletz, Thomas, et al. "EMT in cancer." Nature Reviews Cancer 18.2 (2018): 128-134.


Last updated on 2018-09-10 at 02:16