Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Blümcke I, Spreafico R, Haaker G, Coras R, Kobow K, Bien CG, Pfaefflin M, Elger C, Widman G, Schramm J, Becker A, Braun KP, Leijten F, Baayen JC, Aronica E, Chassoux F, Hamer H, Stefan H, Roessler K, Thom M, Walker MC, Sisodiya SM, Duncan JS, Mcevoy AW, Pieper T, Holthausen H, Kudernatsch M, Meencke HJ, Kahane P, Schulze-Bonhage A, Zentner J, Heiland DH, Urbach H, Steinhoff BJ, Bast T, Tassi L, Lo Russo G, Ozkara C, Oz B, Krsek P, Vogelgesang S, Runge U, Lerche H, Weber Y, Honavar M, Pimentel J, Arzimanoglou A, Ulate-Campos A, Noachtar S, Hartl E, Schijns O, Guerrini R, Barba C, Jacques TS, Cross JH, Feucht M, Muehlebner A, Grunwald T, Trinka E, Winkler PA, Gil-Nagel A, Delgado RT, Mayer T, Lutz M, Zountsas B, Garganis K, Rosenow F, Hermsen A, Von Oertzen TJ, Diepgen TL, Avanzini G
Zeitschrift: New England Journal of Medicine
Jahr der Veröffentlichung: 2017
Band: 377
Heftnummer: 17
Seitenbereich: 1648-1656
ISSN: 0028-4793


Abstract


Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy.We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%).The onset of seizures occurred before 18 years of age in 75.9% of patients overall, and 72.5% of the patients underwent surgery as adults. The mean duration of epilepsy before surgical resection was 20.1 years among adults and 5.3 years among children. The temporal lobe was involved in 71.9% of operations. There were 36 histopathological diagnoses in seven major disease categories. The most common categories were hippocampal sclerosis, found in 36.4% of the patients (88.7% of cases were in adults), tumors (mainly ganglioglioma) in 23.6%, and malformations of cortical development in 19.8% (focal cortical dysplasia was the most common type, 52.7% of cases of which were in children). No histopathological diagnosis could be established for 7.7% of the patients.In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were the second most common lesion in both groups. (Funded by the European Union and others.).



FAU-Autoren / FAU-Herausgeber

Blümcke, Ingmar Prof. Dr.
Lehrstuhl für Neuropathologie
Hamer, Hajo Prof. Dr. med.
Professur für Epileptologie
Stefan, Hermann Prof. Dr.
Medizinische Fakultät


Autor(en) der externen Einrichtung(en)
Albert-Ludwigs-Universität Freiburg
Centre hospitalier Sainte-Anne
Centro Hospitalar Lisboa Norte E.P.E.
Eberhard Karls Universität Tübingen
Epilepsie-Zentrum Berlin-Brandenburg / Institut für Diagnostik der Epilepsien gGmbH (IDE)
Epilepsiezentrum Kork
Foundation of the Carlo Besta Neurological Institute (IRCCS)
Goethe-Universität Frankfurt am Main
Great Ormond Street Hospital (GOSH)
Hospices Civils de Lyon (CHU)
Istanbul University / İstanbul Üniversitesi
Kepler Universitätsklinikum (KUK)
Kleinwachau - Sächsisches Epilepsiezentrum Radeberg gGmbH
Krankenhaus Mara
Ludwig-Maximilians-Universität (LMU)
Maastricht University
Medizinische Universität Wien
Ospedale Niguarda Ca' Granda
Paracelsus Medizinische Privatuniversität
Rheinische Friedrich-Wilhelms-Universität Bonn
Ruber International Hospital
Ruprecht-Karls-Universität Heidelberg
Schön Kliniken
St. Luke's Hospital / Κλινική Άγιος Λουκάς
Unidade Local de Saúde de Matosinhos
Università degli Studi di Firenze / University of Florence
Universitätsklinikum Freiburg
Universitätsmedizin Greifswald / Universitätsklinikum Greifswald
Universitätsspital Zürich (USZ)
University College London (UCL) (University of London)
University Medical Centre Utrecht (UMC Utrecht)
University of Amsterdam
University of Grenoble Alpes (UGA) / Université de Grenoble
Univerzita Karlova v Praze / Charles University in Prague
Vrije Universiteit Amsterdam (VU) / University Amsterdam


Zitierweisen

APA:
Blümcke, I., Spreafico, R., Haaker, G., Coras, R., Kobow, K., Bien, C.G.,... Avanzini, G. (2017). Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery. New England Journal of Medicine, 377(17), 1648-1656. https://dx.doi.org/10.1056/NEJMoa1703784

MLA:
Blümcke, Ingmar, et al. "Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery." New England Journal of Medicine 377.17 (2017): 1648-1656.

BibTeX: 

Zuletzt aktualisiert 2018-09-10 um 02:23