Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Sluijter JPG, Davidson SM, Boulanger CM, Buzas EI, De Kleijn DPV, Engel F, Giricz Z, Hausenloy DJ, Kishore R, Lecour S, Leor J, Madonna R, Perrino C, Prunier F, Sahoo S, Schiffelers RM, Schulz R, Van Laake LW, Ytrehus K, Ferdinandy P
Zeitschrift: Cardiovascular Research
Jahr der Veröffentlichung: 2018
Band: 114
Heftnummer: 1
Seitenbereich: 19-34
ISSN: 0008-6363


Abstract


Extracellular vesicles (EVs)-particularly exosomes and microvesicles (MVs)-are attracting considerable interest in the cardiovascular field as the wide range of their functions is recognized. These capabilities include transporting regulatory molecules including different RNA species, lipids, and proteins through the extracellular space including blood and delivering these cargos to recipient cells to modify cellular activity. EVs powerfully stimulate angiogenesis, and can protect the heart against myocardial infarction. They also appear to mediate some of the paracrine effects of cells, and have therefore been proposed as a potential alternative to cell-based regenerative therapies. Moreover, EVs of different sources may be useful biomarkers of cardiovascular disease identities. However, the methods used for the detection and isolation of EVs have several limitations and vary widely between studies, leading to uncertainties regarding the exact population of EVs studied and how to interpret the data. The number of publications in the exosome and MV field has been increasing exponentially in recent years and, therefore, in this ESC Working Group Position Paper, the overall objective is to provide a set of recommendations for the analysis and translational application of EVs focussing on the diagnosis and therapy of the ischaemic heart. This should help to ensure that the data from emerging studies are robust and repeatable, and optimize the pathway towards the diagnostic and therapeutic use of EVs in clinical studies for patient benefit.



FAU-Autoren / FAU-Herausgeber

Engel, Felix Prof. Dr. rer. nat.
Professur für Experimentelle Nieren- und Kreislaufforschung


Autor(en) der externen Einrichtung(en)
Icahn School of Medicine at Mount Sinai
Justus-Liebig-Universität Gießen
National University of Singapore (NUS)
Paris-Cardiovascular Research Center / Paris-Centre de Recherche Cardiovasculaire (PARCC)
Semmelweis University
Tel Aviv University
Temple University
Università degli Studi di Napoli Federico II
Università degli Studi Gabriele D'Annunzio
Université d'Angers
Universiteit Utrecht (UU) / Utrecht University
University College London (UCL) (University of London)
University Medical Centre Utrecht (UMC Utrecht)
University of Cape Town (UCT)
University of Tromsø


Zitierweisen

APA:
Sluijter, J.P.G., Davidson, S.M., Boulanger, C.M., Buzas, E.I., De Kleijn, D.P.V., Engel, F.,... Ferdinandy, P. (2018). Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology. Cardiovascular Research, 114(1), 19-34. https://dx.doi.org/10.1093/cvr/cvx211

MLA:
Sluijter, Joost Petrus Gerardus, et al. "Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology." Cardiovascular Research 114.1 (2018): 19-34.

BibTeX: 

Zuletzt aktualisiert 2018-08-10 um 08:32