Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

Journal article


Publication Details

Author(s): Perrino C, Barabasi AL, Condorelli G, Davidson SM, De Windt L, Dimmeler S, Engel F, Hausenloy DJ, Hill JA, Van Laake LW, Lecour S, Leor J, Madonna R, Mayr M, Prunier F, Sluijter JPG, Schulz R, Thum T, Ytrehus K, Ferdinandy P
Journal: Cardiovascular Research
Publication year: 2017
Volume: 113
Journal issue: 7
Pages range: 725-736
ISSN: 0008-6363


Abstract


Despite advances in myocardial reperfusion therapies, acute myocardial ischaemia/reperfusion injury and consequent ischaemic heart failure represent the number one cause of morbidity and mortality in industrialized societies. Although different therapeutic interventions have been shown beneficial in preclinical settings, an effective cardioprotective or regenerative therapy has yet to be successfully introduced in the clinical arena. Given the complex pathophysiology of the ischaemic heart, large scale, unbiased, global approaches capable of identifying multiple branches of the signalling networks activated in the ischaemic/reperfused heart might be more successful in the search for novel diagnostic or therapeutic targets. High-throughput techniques allow high-resolution, genome-wide investigation of genetic variants, epigenetic modifications, and associated gene expression profiles. Platforms such as proteomics and metabolomics (not described here in detail) also offer simultaneous readouts of hundreds of proteins and metabolites. Isolated omics analyses usually provide Big Data requiring large data storage, advanced computational resources and complex bioinformatics tools. The possibility of integrating different omics approaches gives new hope to better understand the molecular circuitry activated by myocardial ischaemia, putting it in the context of the human 'diseasome'. Since modifications of cardiac gene expression have been consistently linked to pathophysiology of the ischaemic heart, the integration of epigenomic and transcriptomic data seems a promising approach to identify crucial disease networks. Thus, the scope of this Position Paper will be to highlight potentials and limitations of these approaches, and to provide recommendations to optimize the search for novel diagnostic or therapeutic targets for acute ischaemia/reperfusion injury and ischaemic heart failure in the post-genomic era.



FAU Authors / FAU Editors

Engel, Felix Prof. Dr. rer. nat.
Professur für Experimentelle Nieren- und Kreislaufforschung


External institutions with authors

Goethe-Universität Frankfurt am Main
Istituto Clinico Humanitas
Justus-Liebig-Universität Gießen
King’s College London
Maastricht University
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Northeastern University
Semmelweis University
Tel Aviv University
Università degli Studi di Napoli Federico II
Università degli Studi Gabriele D'Annunzio
Université d'Angers
University College London (UCL)
University Medical Centre Utrecht (UMC Utrecht)
University of Cape Town (UCT)
University of Texas Southwestern Medical Center (UT Southwestern)
University of Tromsø


How to cite

APA:
Perrino, C., Barabasi, A.-L., Condorelli, G., Davidson, S.M., De Windt, L., Dimmeler, S.,... Ferdinandy, P. (2017). Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. Cardiovascular Research, 113(7), 725-736. https://dx.doi.org/10.1093/cvr/cvx070

MLA:
Perrino, Cinzia, et al. "Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart." Cardiovascular Research 113.7 (2017): 725-736.

BibTeX: 

Last updated on 2019-24-07 at 07:28