Associations between MRI-defined structural pathology and generalized and localized knee pain - the Oulu Knee Osteoarthritis study

Journal article


Publication Details

Author(s): Kaukinen P, Podlipska J, Guermazi A, Niinimaki J, Lehenkari P, Roemer F, Nieminen MT, Koski JM, Arokoski JPA, Saarakkala S
Journal: Osteoarthritis and Cartilage
Publication year: 2016
Volume: 24
Journal issue: 9
Pages range: 1565-76
ISSN: 1063-4584


Abstract


To determine the associations between multi-feature structural pathology assessed using magnetic resonance imaging (MRI) and the presence of knee pain, and to determine the associations between the locations of structural changes and different knee pain patterns.Eighty symptomatic subjects with knee pain and suspicion or diagnosis of knee OA and 63 asymptomatic subjects underwent knee MRI. Severity of structural changes was graded by MRI Osteoarthritis Knee Score (MOAKS) in separate knee locations. The associations between cartilage damage, bone marrow lesions (BMLs), osteophytes, Hoffa's synovitis, effusion-synovitis, meniscal damage and structural pathologies in ligaments, tendons and bursas and both the presence of pain and the knee pain patterns were assessed.The presence of Hoffa's synovitis (adjusted RR 1.6, 95% CI 1.2-1.3) and osteophytes in any region (2.07, 1.19-3.60) was significantly associated with the presence of pain. Any Hoffa's synovitis was associated with patellar pain (adjusted RR 4.70, 95% CI 1.19-3.60) and moderate-to-severe Hoffa's synovitis with diffuse pain (2.25, 1.13-4.50). Medial knee pain was associated with cartilage loss in the medial tibia (adjusted RR 2.66, 95% CI 1.22-5.80), osteophytes in the medial tibia (2.66, 1.17-6.07) and medial femur (2.55, 1.07-6.09), medial meniscal maceration (2.20, 1.01-4.79) and anterior meniscal extrusions (2.78, 1.14-6.75).Hoffa's synovitis and osteophytes were strongly associated with the presence of knee pain. Medial pain was associated most often with medially located structural pathologies.



FAU Authors / FAU Editors

Roemer, Frank Prof. Dr.
Radiologisches Institut


External institutions with authors

Boston University
Mikkeli Central Hospital
Oulun Yliopisto / University of Oulo
University of Eastern Finland


How to cite

APA:
Kaukinen, P., Podlipska, J., Guermazi, A., Niinimaki, J., Lehenkari, P., Roemer, F.,... Saarakkala, S. (2016). Associations between MRI-defined structural pathology and generalized and localized knee pain - the Oulu Knee Osteoarthritis study. Osteoarthritis and Cartilage, 24(9), 1565-76. https://dx.doi.org/10.1016/j.joca.2016.05.001

MLA:
Kaukinen, P., et al. "Associations between MRI-defined structural pathology and generalized and localized knee pain - the Oulu Knee Osteoarthritis study." Osteoarthritis and Cartilage 24.9 (2016): 1565-76.

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Last updated on 2018-08-10 at 08:31