Deficit in acoustic signal-in-noise detection in glycine receptor ?3 subunit knockout mice
Tziridis K, Buerbank S, Eulenburg V, Dlugaiczyk J, Schulze H (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 45
Pages Range: 581-586
Journal Issue: 4
DOI: 10.1111/ejn.13489
Abstract
Hearing is an essential sense for communication in animals and humans. Normal function of the cochlea of higher vertebrates relies on a fine-tuned interplay of afferent and efferent innervation of both inner and outer hair cells. Efferent inhibition is controlled via olivocochlear feedback loops, mediated mainly by acetylcholine, ?-aminobutyric acid (GABA) and glycine, and is one of the first sites affected by synapto- and neuropathy in the development of hearing loss. While the functions of acetylcholine, GABA and other inhibitory transmitters within these feedback loops are at least partially understood, especially the function of glycine still remains elusive. To address this question, we investigated hearing in glycine receptor (GlyR) ?3 knockout (KO) and wildtype (WT) mice. We found no differences in pure tone hearing thresholds at 11.3 and 16 kHz between the two groups as assessed by auditory brainstem response (ABR) measurements. Detailed analysis of the ABR waves at 11.3 kHz, however, revealed a latency decrease of wave III and an amplitude increase of wave IV in KO compared to WT animals. GlyR?3 KO animals showed significantly impaired prepulse inhibition of the auditory startle response in a noisy environment, indicating that GlyR?3-mediated glycinergic inhibition is important for signal-in-noise detection.
Authors with CRIS profile
Konstantin Tziridis
Department of Otorhinolaryngology – Head and Neck Surgery
Volker Eulenburg
Medizinische Fakultät
Holger Schulze
Professur für Experimentelle HNO-Heilkunde
Involved external institutions
Germany (DE)How to cite
APA:
Tziridis, K., Buerbank, S., Eulenburg, V., Dlugaiczyk, J., & Schulze, H. (2017). Deficit in acoustic signal-in-noise detection in glycine receptor ?3 subunit knockout mice. European Journal of Neuroscience, 45(4), 581-586. https://dx.doi.org/10.1111/ejn.13489
MLA:
Tziridis, Konstantin, et al. "Deficit in acoustic signal-in-noise detection in glycine receptor ?3 subunit knockout mice." European Journal of Neuroscience 45.4 (2017): 581-586.
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