Magnetic resonance imaging (MRI)-defined cartilage degeneration and joint pain are associated with poor physical function in knee osteoarthritis - the Oulu Knee Osteoarthritis study

Journal article


Publication Details

Author(s): Kaukinen P, Podlipska J, Guermazi A, Niinimaki J, Lehenkari P, Roemer F, Nieminen MT, Koski JM, Saarakkala S, Arokoski JPA
Journal: Osteoarthritis and Cartilage
Publication year: 2017
Volume: 25
Journal issue: 11
Pages range: 1829-1840
ISSN: 1063-4584


Abstract


The main aim was to investigate the associations between Magnetic Resonance Imaging (MRI)-defined structural pathologies of the knee and physical function.A cohort study with frequency matching on age and sex with eighty symptomatic subjects with knee pain and suspicion or diagnosis of knee osteoarthritis (OA) and 57 asymptomatic subjects was conducted. The subjects underwent knee MRI, and the severity of structural changes was graded by MRI Osteoarthritis Knee Score (MOAKS) in separate knee locations. WOMAC function subscores were recorded and physical function tests (20-m and 5-min walk, stair ascending and descending, timed up & go and repeated sit-to-stand tests) performed. The association between MRI-defined structural pathologies and physical function tests and WOMAC function subscores were evaluated by linear regression analysis with adjustment for demographic factors, other MRI-features and pain with using effect size (ES) as a measure of the magnitude of an association.Cartilage degeneration showed significant association with poor physical performance in TUG-, stair ascending and descending-, 20-m- and 5-min walk-tests (ESs in the subjects with cartilage degeneration anywhere between 0.134 [95%CI 0.037-0.238] and 0.224 [0.013-0.335]) and with increased WOMAC function subscore (ES in the subjects with cartilage degeneration anywhere 0.088 [0.012-0.103]). Also, lateral meniscus maceration and extrusion were associated with poor performance in stair ascending test (ESs 0.067 [0.008-0.163] and 0.077 [0.012-0.177]).After adjustments cartilage degeneration was associated with both decreased self-reported physical function and poor performance in the physical function tests. Furthermore, subjects with lateral meniscus maceration and extrusions showed significantly worse performance in stair ascending tests.



FAU Authors / FAU Editors

Roemer, Frank Prof. Dr.
Radiologisches Institut


External institutions with authors

Boston University
Helsinki University Central Hospital (HUCH) / Helsingin seudun yliopistollinen keskussairaala (HYKS)
Mikkeli Central Hospital
Oulun Yliopisto / University of Oulo
University of Eastern Finland


How to cite

APA:
Kaukinen, P., Podlipska, J., Guermazi, A., Niinimaki, J., Lehenkari, P., Roemer, F.,... Arokoski, J.P.A. (2017). Magnetic resonance imaging (MRI)-defined cartilage degeneration and joint pain are associated with poor physical function in knee osteoarthritis - the Oulu Knee Osteoarthritis study. Osteoarthritis and Cartilage, 25(11), 1829-1840. https://dx.doi.org/10.1016/j.joca.2017.07.002

MLA:
Kaukinen, P., et al. "Magnetic resonance imaging (MRI)-defined cartilage degeneration and joint pain are associated with poor physical function in knee osteoarthritis - the Oulu Knee Osteoarthritis study." Osteoarthritis and Cartilage 25.11 (2017): 1829-1840.

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Last updated on 2018-08-10 at 08:30