Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology

Ripperger T, Bielack SS, Borkhardt A, Brecht IB, Burkhardt B, Calaminus G, Debatin KM, Deubzer H, Dirksen U, Eckert C, Eggert A, Erlacher M, Fleischhack G, Fruehwald MC, Gnekow A, Goehring G, Graf N, Hanenberg H, Hauer J, Hero B, Hettmer S, Von Hoff K, Horstmann M, Hoyer J, Illig T, Kaatsch P, Kappler R, Kerl K, Klingebiel T, Kontny U, Kordes U, Koerholz D, Koscielniak E, Kramm CM, Kuhlen M, Kulozik AE, Lamottke B, Leuschner I, Lohmann DR, Meinhardt A, Metzler M, Meyer LH, Moser O, Nathrath M, Niemeyer CM, Nustede R, Pajtler KW, Paret C, Rasche M, Reinhardt D, Riess O, Russo A, Rutkowski S, Schlegelberger B, Schneider D, Schneppenheim R, Schrappe M, Schroeder C, Von Schweinitz D, Simon T, Sparber-Sauer M, Spix C, Stanulla M, Steinemann D, Strahm B, Temming P, Thomay K, Von Bueren AO, Vorwerk P, Witt O, Wlodarski M, Woessmann W, Zenker M, Zimmermann S, Pfister SM, Kratz CP (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Book Volume: 173

Pages Range: 1017-1037

Journal Issue: 4

DOI: 10.1002/ajmg.a.38142

Abstract

Heritable predisposition is an important cause of cancer in children and adolescents. Although a large number of cancer predisposition genes and their associated syndromes and malignancies have already been described, it appears likely that there are more pediatric cancer patients in whom heritable cancer predisposition syndromes have yet to be recognized. In a consensus meeting in the beginning of 2016, we convened experts in Human Genetics and Pediatric Hematology/Oncology to review the available data, to categorize the large amount of information, and to develop recommendations regarding when a cancer predisposition syndrome should be suspected in a young oncology patient. This review summarizes the current knowledge of cancer predisposition syndromes in pediatric oncology and provides essential information on clinical situations in which a childhood cancer predisposition syndrome should be suspected.

Authors with CRIS profile

Involved external institutions

Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Klinikum Augsburg Germany (DE) Klinikum Stuttgart Germany (DE) Albert-Ludwigs-Universität Freiburg Germany (DE) Otto-von-Guericke-Universität Magdeburg Germany (DE) Geneva University Hospitals / Hôpitaux universitaires de Genève (HUG) Switzerland (CH) Christian-Albrechts-Universität zu Kiel Germany (DE) Klinikum Dortmund Germany (DE) Universitätsklinikum Göttingen Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Eberhard Karls Universität Tübingen Germany (DE) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich Germany (DE) Universitätsklinikum Ulm Germany (DE) Universitätsklinikum Essen Germany (DE) Universitätsklinikum Heidelberg Germany (DE) Justus-Liebig-Universität Gießen Germany (DE) Ludwig-Maximilians-Universität (LMU) Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) Germany (DE) Universität zu Köln Germany (DE) Universitätsklinikum Düsseldorf Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Universitätsklinikum Münster Germany (DE) Universitätsklinikum Tübingen Germany (DE)

How to cite

APA:

Ripperger, T., Bielack, S.S., Borkhardt, A., Brecht, I.B., Burkhardt, B., Calaminus, G.,... Kratz, C.P. (2017). Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology. American Journal of Medical Genetics Part A, 173(4), 1017-1037. https://dx.doi.org/10.1002/ajmg.a.38142

MLA:

Ripperger, Tim, et al. "Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology." American Journal of Medical Genetics Part A 173.4 (2017): 1017-1037.

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