Multifocal electroretinography after high dose chloroquine therapy for malaria

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: de Carvalho AC, Schwarz M, Souza GdS, Gomes BD, Rosa AAM, da Silva Ventura AMR, de Souza JM, Silveira LCdL, Kremers J
Zeitschrift: Journal of Ophthalmic & Vision Research
Jahr der Veröffentlichung: 2013
Band: 8
Seitenbereich: 193-8
ISSN: 2008-2010


Abstract


To investigate changes in multifocal electroretinography (mfERG) parameters associated with high dose chloroquine therapy for treatment of malaria in the Amazonia region of Brazil.Forty-eight subjects who had received chloroquine treatment for single or multiple malaria infections with a cumulative dose ranging from 1,050 to 27,000mg were included. The control group consisted of 37 healthy aged-matched subjects. Data was collected on amplitude and implicit time of the N1, P1 and N2 waves in the central macular hexagon (R1) and in five concentric rings at different retinal eccentricities (R2-R6).No significant difference was observed in any mfERG parameter between chloroquine treated patients and control subjects. A comparison with previous data obtained from patients with rheumatologic disorders in the same region of Brazil who had received larger cumulative doses of chloroquine and had displayed mfERG changes, indicated that retinal toxicity seems to be dependent on cumulative dose.Lack of mfERG changes in the current study suggests that intensive high dose chloroquine therapy for treatment of malaria is not associated with retinal toxicity.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Kremers, Jan Prof. Dr.
Professur für Experimentelle Augenheilkunde
Schwarz, Martin
Professur für Experimentelle Augenheilkunde


Einrichtungen weiterer Autorinnen und Autoren

Universidade Federal do Pará (UFPA)


Zitierweisen

APA:
de Carvalho, A.C., Schwarz, M., Souza, G.d.S., Gomes, B.D., Rosa, A.A.M., da Silva Ventura, A.M.R.,... Kremers, J. (2013). Multifocal electroretinography after high dose chloroquine therapy for malaria. Journal of Ophthalmic & Vision Research, 8, 193-8.

MLA:
de Carvalho, Aline Correa, et al. "Multifocal electroretinography after high dose chloroquine therapy for malaria." Journal of Ophthalmic & Vision Research 8 (2013): 193-8.

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Zuletzt aktualisiert 2019-21-07 um 08:01