Multifocal electroretinography after high dose chloroquine therapy for malaria

de Carvalho AC, Schwarz M, Souza GdS, Gomes BD, Rosa AAM, da Silva Ventura AMR, de Souza JM, Silveira LCdL, Kremers J (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Journal of Ophthalmic & Vision Research Ophthalmic Research Center

Book Volume: 8

Pages Range: 193-8

Issue: 3

Abstract

To investigate changes in multifocal electroretinography (mfERG) parameters associated with high dose chloroquine therapy for treatment of malaria in the Amazonia region of Brazil.Forty-eight subjects who had received chloroquine treatment for single or multiple malaria infections with a cumulative dose ranging from 1,050 to 27,000mg were included. The control group consisted of 37 healthy aged-matched subjects. Data was collected on amplitude and implicit time of the N1, P1 and N2 waves in the central macular hexagon (R1) and in five concentric rings at different retinal eccentricities (R2-R6).No significant difference was observed in any mfERG parameter between chloroquine treated patients and control subjects. A comparison with previous data obtained from patients with rheumatologic disorders in the same region of Brazil who had received larger cumulative doses of chloroquine and had displayed mfERG changes, indicated that retinal toxicity seems to be dependent on cumulative dose.Lack of mfERG changes in the current study suggests that intensive high dose chloroquine therapy for treatment of malaria is not associated with retinal toxicity.

Authors with CRIS profile

Martin Schwarz Professur für Experimentelle Augenheilkunde Jan Kremers Professur für Experimentelle Augenheilkunde

Involved external institutions

Universidade Federal do Pará (UFPA) BR Brazil (BR)

How to cite

APA:

de Carvalho, A.C., Schwarz, M., Souza, G.d.S., Gomes, B.D., Rosa, A.A.M., da Silva Ventura, A.M.R.,... Kremers, J. (2013). Multifocal electroretinography after high dose chloroquine therapy for malaria. Journal of Ophthalmic & Vision Research, 8, 193-8.

MLA:

de Carvalho, Aline Correa, et al. "Multifocal electroretinography after high dose chloroquine therapy for malaria." Journal of Ophthalmic & Vision Research 8 (2013): 193-8.

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