Levels of Aqueous Humor Trace Elements in Patients with Non-Exsudative Age-related Macular Degeneration: A Case-control Study

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Jünemann A, Stopa P, Michalke B, Chaudhri A, Reulbach U, Huchzermeyer C, Schlötzer-Schrehardt U, Kruse F, Zrenner E, Rejdak R
Zeitschrift: PLoS ONE
Jahr der Veröffentlichung: 2013
Band: 8
Heftnummer: 2
Seitenbereich: e56734
ISSN: 1932-6203


Abstract


Trace elements might play a role in the complex multifactorial pathogenesis of age-related macular degeneration (AMD). The aim of this study was to measure alterations of trace elements levels in aqueous humor of patients with non-exsudative (dry) AMD.For this pilot study, aqueous humor samples were collected from patients undergoing cataract surgery. 12 patients with dry AMD (age 77.9±6.62, female 8, male 4) and 11 patients without AMD (age 66.6±16.7, female 7, male 4) were included. Aqueous levels of cadmium, cobalt, copper, iron, manganese, selenium, and zinc were measured by use of Flow-Injection-Inductively-Coupled-Plasma-Mass-Spectrometry (FI-ICP-MS), quality controlled with certified standards.PATIENTS WITH AMD HAD SIGNIFICANTLY HIGHER AQUEOUS HUMOR LEVELS OF CADMIUM (MEDIAN: 0.70 µmol/L, IQR: 0.40-0.84 vs. 0.06 µmol/L; IQR: 0.01-.018; p = 0.002), cobalt (median: 3.1 µmol/L, IQR: 2.62-3.15 vs. 1.17 µmol/L; IQR: 0.95-1.27; p<0.001), iron (median: 311 µmol/L, IQR: 289-329 vs. 129 µmol/L; IQR: 111-145; p<0.001) and zinc (median: 23.1 µmol/L, IQR: 12.9-32.6 vs. 5.1 µmol/L; IQR: 4.4-9.4; p = 0.020) when compared with patients without AMD. Copper levels were significantly reduced in patients with AMD (median: 16.2 µmol/L, IQR: 11.4-31.3 vs. 49.9 µmol/L; IQR: 32.0-.142.0; p = 0.022) when compared to those without. No significant differences were observed in aqueous humor levels of manganese and selenium between patients with and without AMD. After an adjustment for multiple testing, cadmium, cobalt, copper and iron remained a significant factor in GLM models (adjusted for age and gender of the patients) for AMD.Alterations of trace element levels support the hypothesis that cadmium, cobalt, iron, and copper are involved in the pathogenesis of AMD.



FAU-Autoren / FAU-Herausgeber

Chaudhri, Anwar Prof. Dr.
Lehrstuhl für Bioanorganische Chemie
Huchzermeyer, Cord PD Dr.
Augenklinik
Jünemann, Anselm Prof. Dr.
Medizinische Fakultät
Kruse, Friedrich Prof. Dr.
Lehrstuhl für Augenheilkunde
Schlötzer-Schrehardt, Ursula apl. Prof. Dr.
Medizinische Fakultät


Autor(en) der externen Einrichtung(en)
Eberhard Karls Universität Tübingen
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU)
Medical University of Lublin / Uniwersytet Medyczny w Lublinie
Trinity College Dublin


Zitierweisen

APA:
Jünemann, A., Stopa, P., Michalke, B., Chaudhri, A., Reulbach, U., Huchzermeyer, C.,... Rejdak, R. (2013). Levels of Aqueous Humor Trace Elements in Patients with Non-Exsudative Age-related Macular Degeneration: A Case-control Study. PLoS ONE, 8(2), e56734. https://dx.doi.org/10.1371/journal.pone.0056734

MLA:
Jünemann, Anselm, et al. "Levels of Aqueous Humor Trace Elements in Patients with Non-Exsudative Age-related Macular Degeneration: A Case-control Study." PLoS ONE 8.2 (2013): e56734.

BibTeX: 

Zuletzt aktualisiert 2018-08-10 um 08:28