Mechanisms, clinical profile and role of prostaglandin and prostamide analogues in antiglaucomatous therapy
Yu A, Welge-Lüssen UC (2013)
Publication Type: Journal article
Publication year: 2013
Journal
Book Volume: 230
Pages Range: 127-32
Journal Issue: 2
Abstract
Prostaglandin and prostamide analogues belong to a new substance group which came into the market in the 1990s. They have revolutionised antiglaucomatous therapy by their once-daily dosing regimen and fewer side effects. Today, prostaglandin and prostamide analogues are approved as first-line therapy for patients with primary open-angle glaucoma and ocular hypertension. They lower the intraocular pressure primarily by increasing the uveoscleral outflow. Recent investigations have shown that they also improve the trabecular outflow facility and thus the conventional outflow pathways. Prostaglandin and prostamide analogues are highly efficient in lowering the intraocular pressure, for which they are superior to other antiglaucomatous substance groups. In particular, they appear to have a good control of 24-hour intraocular pressure fluctuations by primarily improving the outflow pathways. Furthermore, they have less systemic side effects than ?-blockers. However, their use is often associated with higher costs. In case of undesirable events, they mostly present with ocular symptoms. Based on their good clinical profile, prostaglandin and prostamide analogues play an important role in the primary and additive therapy for glaucoma.
Additional Organisation(s)
Involved external institutions
Germany (DE)How to cite
APA:
Yu, A., & Welge-Lüssen, U.-C. (2013). Mechanisms, clinical profile and role of prostaglandin and prostamide analogues in antiglaucomatous therapy. Klinische Monatsblätter für Augenheilkunde, 230(2), 127-32. https://dx.doi.org/10.1055/s-0032-1327946
MLA:
Yu, A., and Ulrich-Christoph Welge-Lüssen. "Mechanisms, clinical profile and role of prostaglandin and prostamide analogues in antiglaucomatous therapy." Klinische Monatsblätter für Augenheilkunde 230.2 (2013): 127-32.
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