Mechanisms, clinical profile and role of prostaglandin and prostamide analogues in antiglaucomatous therapy

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Yu A, Welge-Lüssen UC
Zeitschrift: Klinische Monatsblätter für Augenheilkunde
Jahr der Veröffentlichung: 2013
Band: 230
Heftnummer: 2
Seitenbereich: 127-32
ISSN: 0023-2165


Abstract


Prostaglandin and prostamide analogues belong to a new substance group which came into the market in the 1990s. They have revolutionised antiglaucomatous therapy by their once-daily dosing regimen and fewer side effects. Today, prostaglandin and prostamide analogues are approved as first-line therapy for patients with primary open-angle glaucoma and ocular hypertension. They lower the intraocular pressure primarily by increasing the uveoscleral outflow. Recent investigations have shown that they also improve the trabecular outflow facility and thus the conventional outflow pathways. Prostaglandin and prostamide analogues are highly efficient in lowering the intraocular pressure, for which they are superior to other antiglaucomatous substance groups. In particular, they appear to have a good control of 24-hour intraocular pressure fluctuations by primarily improving the outflow pathways. Furthermore, they have less systemic side effects than ?-blockers. However, their use is often associated with higher costs. In case of undesirable events, they mostly present with ocular symptoms. Based on their good clinical profile, prostaglandin and prostamide analogues play an important role in the primary and additive therapy for glaucoma.




Zusätzliche Organisationseinheit(en)
Augenklinik


Autor(en) der externen Einrichtung(en)
Ludwig-Maximilians-Universität (LMU)


Zitierweisen

APA:
Yu, A., & Welge-Lüssen, U.-C. (2013). Mechanisms, clinical profile and role of prostaglandin and prostamide analogues in antiglaucomatous therapy. Klinische Monatsblätter für Augenheilkunde, 230(2), 127-32. https://dx.doi.org/10.1055/s-0032-1327946

MLA:
Yu, A., and Ulrich-Christoph Welge-Lüssen. "Mechanisms, clinical profile and role of prostaglandin and prostamide analogues in antiglaucomatous therapy." Klinische Monatsblätter für Augenheilkunde 230.2 (2013): 127-32.

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Zuletzt aktualisiert 2018-08-10 um 08:28