Sensitivity of serum concentration of cartilage biomarkers to 21-days of bed rest

Journal article


Publication Details

Author(s): Liphardt AM, Mündermann A, Andriacchi TP, Achtzehn S, Heer M, Mester J
Journal: Journal of Orthopaedic Research
Publication year: 2017
ISSN: 0736-0266


Abstract


The objective of the study was to test the hypothesis that serum levels of cartilage oligomeric matrix protein (COMP) would decrease and serum levels of tumor-necrosis factor alpha (TNF-?) and selected matrix metalloproteinases (MMPs) would increase in response to bed rest (BR) and that these changes are unaffected by the intake of potassium bicarbonate or whey protein. Seven and 9 healthy male subjects participated in two 21-day 6° head down tilt crossover BR-studies with nutrition interventions. Serum samples were taken before, during, and after BR and biomarker concentrations were measured using commercial enzyme-linked immunosorbent assays. MMP-3 during BR was significantly lower than at baseline (reduction greater 20%; P<0.001). MMP-3 increased significantly from 14 to 21 days of BR (+7%; P=0.049). COMP during BR was significantly lower than at baseline (reduction greater 20%; P<0.001). MMP-3 and COMP returned to baseline within one day after BR. MMP-9 on day 3 of BR was significantly lower than at baseline (-31%; P<0.033) and on days 3, 5 and 14 of BR significantly lower than at the end of and after BR (reduction greater 35%; P<0.030). The nutritional countermeasures did not affect these results. The observed changes in cartilage biomarkers may be caused by altered cartilage metabolism in response to the lack of mechanical stimulus during BR and inflammatory biomarkers may play a role in changes in biomarker levels.Immobilization independently from injury can cause altered cartilage biomarker concentration. This article is protected by copyright. All rights reserved.



FAU Authors / FAU Editors

Liphardt, Anna-Maria Dr.
Medizinische Klinik 3 - Rheumatologie und Immunologie


External institutions with authors

Deutsche Sporthochschule Köln
Stanford University
Universitätsspital Basel


How to cite

APA:
Liphardt, A.-M., Mündermann, A., Andriacchi, T.P., Achtzehn, S., Heer, M., & Mester, J. (2017). Sensitivity of serum concentration of cartilage biomarkers to 21-days of bed rest. Journal of Orthopaedic Research. https://dx.doi.org/10.1002/jor.23786

MLA:
Liphardt, Anna-Maria, et al. "Sensitivity of serum concentration of cartilage biomarkers to 21-days of bed rest." Journal of Orthopaedic Research (2017).

BibTeX: 

Last updated on 2018-08-10 at 08:27