Increased plasma soluble urokinase plasminogen activator receptor levels in systemic sclerosis: possible association with microvascular abnormalities and extent of fibrosis

Journal article


Publication Details

Author(s): Legany N, Toldi G, Distler J, Beyer C, Szalay B, Kovacs L, Vasarhelyi B, Balog A
Journal: Clinical Chemistry and Laboratory Medicine
Publication year: 2015
Volume: 53
Journal issue: 11
Pages range: 1799-805
ISSN: 1434-6621


Abstract

Urokinase plasminogen activator receptor (uPAR) is a key component of the fibrinolytic system involved in extracellular matrix remodeling and angiogenesis. Novel animal models supported the key role of uPAR not only in fibrosis but also in systemic sclerosis (SSc)-related microvascular abnormalities. The aim of this study was to investigate plasma soluble uPAR (suPAR) levels in SSc, and their association with organ-specific involvement.suPAR concentrations were measured by ELISA in SSc patient (n=83) and in healthy controls (n=29). Simultaneously, CRP and ESR were assessed. Detailed clinical data including skin, lung, heart and microvascular characteristics were evaluated at sampling.suPAR values were higher in SSc patients than in controls. Subgroup analysis showed higher suPAR values in diffuse cutaneous- than in limited cutaneous SSc and correlated with anti-Scl-70+. suPAR levels also associated with pulmonary function test parameters of fibrosis, presence of microvascular lesions (e.g., Raynaud phenomenon, naifold capillaroscopic abnormalities and digital ulcers) and arthritis.Our data indicate that suPAR might be a valuable early diagnostic marker of SSc which also correlates with disease severity.


FAU Authors / FAU Editors

Beyer, Christian PD Dr.
Medizinische Klinik 3 - Rheumatologie und Immunologie
Distler, Jörg PD Dr.
Heisenberg-Professur für Molekulare Mechanismen der Organfibrose


External institutions with authors

Semmelweis University
University of Szeged / József Attila Tudományegyetem Szeged


How to cite

APA:
Legany, N., Toldi, G., Distler, J., Beyer, C., Szalay, B., Kovacs, L.,... Balog, A. (2015). Increased plasma soluble urokinase plasminogen activator receptor levels in systemic sclerosis: possible association with microvascular abnormalities and extent of fibrosis. Clinical Chemistry and Laboratory Medicine, 53(11), 1799-805. https://dx.doi.org/10.1515/cclm-2015-0079

MLA:
Legany, Nora, et al. "Increased plasma soluble urokinase plasminogen activator receptor levels in systemic sclerosis: possible association with microvascular abnormalities and extent of fibrosis." Clinical Chemistry and Laboratory Medicine 53.11 (2015): 1799-805.

BibTeX: 

Last updated on 2018-08-10 at 08:26