Increased plasma soluble urokinase plasminogen activator receptor levels in systemic sclerosis: possible association with microvascular abnormalities and extent of fibrosis

Legany N, Toldi G, Distler J, Beyer C, Szalay B, Kovacs L, Vasarhelyi B, Balog A (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Clinical Chemistry and Laboratory Medicine Walter de Gruyter

Book Volume: 53

Pages Range: 1799-805

Journal Issue: 11

DOI: 10.1515/cclm-2015-0079

Abstract

Urokinase plasminogen activator receptor (uPAR) is a key component of the fibrinolytic system involved in extracellular matrix remodeling and angiogenesis. Novel animal models supported the key role of uPAR not only in fibrosis but also in systemic sclerosis (SSc)-related microvascular abnormalities. The aim of this study was to investigate plasma soluble uPAR (suPAR) levels in SSc, and their association with organ-specific involvement.suPAR concentrations were measured by ELISA in SSc patient (n=83) and in healthy controls (n=29). Simultaneously, CRP and ESR were assessed. Detailed clinical data including skin, lung, heart and microvascular characteristics were evaluated at sampling.suPAR values were higher in SSc patients than in controls. Subgroup analysis showed higher suPAR values in diffuse cutaneous- than in limited cutaneous SSc and correlated with anti-Scl-70+. suPAR levels also associated with pulmonary function test parameters of fibrosis, presence of microvascular lesions (e.g., Raynaud phenomenon, naifold capillaroscopic abnormalities and digital ulcers) and arthritis.Our data indicate that suPAR might be a valuable early diagnostic marker of SSc which also correlates with disease severity.

Authors with CRIS profile

Jörg Distler Professur für Molekulare Mechanismen der Organfibrose Christian Beyer Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

University of Szeged / József Attila Tudományegyetem Szeged HU Hungary (HU) Semmelweis University / Semmelweis Egyetem HU Hungary (HU)

How to cite

APA:

Legany, N., Toldi, G., Distler, J., Beyer, C., Szalay, B., Kovacs, L.,... Balog, A. (2015). Increased plasma soluble urokinase plasminogen activator receptor levels in systemic sclerosis: possible association with microvascular abnormalities and extent of fibrosis. Clinical Chemistry and Laboratory Medicine, 53(11), 1799-805. https://dx.doi.org/10.1515/cclm-2015-0079

MLA:

Legany, Nora, et al. "Increased plasma soluble urokinase plasminogen activator receptor levels in systemic sclerosis: possible association with microvascular abnormalities and extent of fibrosis." Clinical Chemistry and Laboratory Medicine 53.11 (2015): 1799-805.

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