Regulation of the tumor marker Fascin by the viral oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) depends on promoter activation and on a promoter-independent mechanism

Mohr CF, Groß C, Bros M, Reske-Kunz AB, Biesinger B, Thoma-Kreß A (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Virology Elsevier

Book Volume: 485

Pages Range: 481-91

DOI: 10.1016/j.virol.2015.08.025

Abstract

Adult T-cell leukemia/lymphoma is a highly infiltrative neoplasia of CD4(+) T-lymphocytes that occurs in about 5% of carriers infected with the deltaretrovirus human T-cell leukemia virus type 1 (HTLV-1). The viral oncoprotein Tax perturbs cellular signaling pathways leading to upregulation of host cell factors, amongst them the actin-bundling protein Fascin, an invasion marker of several types of cancer. However, transcriptional regulation of Fascin by Tax is poorly understood. In this study, we identified a triple mode of transcriptional induction of Fascin by Tax, which requires (1) NF-?B-dependent promoter activation, (2) a Tax-responsive region in the Fascin promoter, and (3) a promoter-independent mechanism sensitive to the Src family kinase inhibitor PP2. Thus, Tax regulates Fascin by a multitude of signals. Beyond, using Tax-expressing and virus-transformed lymphocytes as a model system, our study is the first to identify the invasion marker Fascin as a novel target of PP2, an inhibitor of metastasis.

Authors with CRIS profile

Christine Groß Institute of Clinical and Molecular Virology Brigitte Biesinger-Zwosta Institute of Clinical and Molecular Virology Andrea Thoma-Kreß Institute of Clinical and Molecular Virology

Related research project(s)

Effects of Tax and p8 proteins on cell-to-cell transmission of Human T-cell lymphotropic virus type 1 (HTLV-1) (C06*) (SFB 796) SFB 796: Steuerungsmechanismen mikrobieller Effektoren in Wirtszellen Jan. 1, 2013 - Dec. 31, 2017

Involved external institutions

Johannes Gutenberg-Universität Mainz (JGU) DE Germany (DE)

How to cite

APA:

Mohr, C.F., Groß, C., Bros, M., Reske-Kunz, A.B., Biesinger, B., & Thoma-Kreß, A. (2015). Regulation of the tumor marker Fascin by the viral oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) depends on promoter activation and on a promoter-independent mechanism. Virology, 485, 481-91. https://dx.doi.org/10.1016/j.virol.2015.08.025

MLA:

Mohr, Caroline F., et al. "Regulation of the tumor marker Fascin by the viral oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) depends on promoter activation and on a promoter-independent mechanism." Virology 485 (2015): 481-91.

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