Superparamagnetic iron oxide nanoparticles as radiosensitizer via enhanced reactive oxygen species formation

Journal article
(Original article)


Publication Details

Author(s): Klein S, Sommer A, Distel L, Neuhuber W, Kryschi C
Journal: Biochemical and Biophysical Research Communications
Publisher: Elsevier
Publication year: 2012
Volume: 425
Journal issue: 2
Pages range: 393-397
ISSN: 0006-291X


Abstract


Internalization of citrate-coated and uncoated superparamagnetic iron oxide nanoparticles by human breast cancer (MCF-7) cells was verified by transmission electron microscopy imaging. Cytotoxicity studies employing metabolic and trypan blue assays manifested their excellent biocompatibility. The production of reactive oxygen species in iron oxide nanoparticle loaded MCF-7 cells was explained to originate from both, the release of iron ions and their catalytically active surfaces. Both initiate the Fenton and Haber-Weiss reaction. Additional oxidative stress caused by X-ray irradiation of MCF-7 cells was attributed to the increase of catalytically active iron oxide nanoparticle surfaces. © 2012 Elsevier Inc.



FAU Authors / FAU Editors

Distel, Luitpold Prof. Dr.
Strahlenklinik
Klein, Stefanie Dr.
Lehrstuhl für Physikalische Chemie I
Kryschi, Carola Prof. Dr.
Professur für Physikalische Chemie
Neuhuber, Winfried Prof. Dr.
Lehrstuhl für Anatomie und Zellbiologie
Sommer, Anja
Lehrstuhl für Physikalische Chemie I


How to cite

APA:
Klein, S., Sommer, A., Distel, L., Neuhuber, W., & Kryschi, C. (2012). Superparamagnetic iron oxide nanoparticles as radiosensitizer via enhanced reactive oxygen species formation. Biochemical and Biophysical Research Communications, 425(2), 393-397. https://dx.doi.org/10.1016/j.bbrc.2012.07.108

MLA:
Klein, Stefanie, et al. "Superparamagnetic iron oxide nanoparticles as radiosensitizer via enhanced reactive oxygen species formation." Biochemical and Biophysical Research Communications 425.2 (2012): 393-397.

BibTeX: 

Last updated on 2019-09-04 at 16:23