Klein S, Sommer A, Distel L, Neuhuber W, Kryschi C (2012)
Publication Type: Journal article, Original article
Publication year: 2012
Original Authors: Klein S., Sommer A., Distel L.V.R., Neuhuber W., Kryschi C.
Publisher: Elsevier
Book Volume: 425
Pages Range: 393-397
Journal Issue: 2
DOI: 10.1016/j.bbrc.2012.07.108
Internalization of citrate-coated and uncoated superparamagnetic iron oxide nanoparticles by human breast cancer (MCF-7) cells was verified by transmission electron microscopy imaging. Cytotoxicity studies employing metabolic and trypan blue assays manifested their excellent biocompatibility. The production of reactive oxygen species in iron oxide nanoparticle loaded MCF-7 cells was explained to originate from both, the release of iron ions and their catalytically active surfaces. Both initiate the Fenton and Haber-Weiss reaction. Additional oxidative stress caused by X-ray irradiation of MCF-7 cells was attributed to the increase of catalytically active iron oxide nanoparticle surfaces. © 2012 Elsevier Inc.
APA:
Klein, S., Sommer, A., Distel, L., Neuhuber, W., & Kryschi, C. (2012). Superparamagnetic iron oxide nanoparticles as radiosensitizer via enhanced reactive oxygen species formation. Biochemical and Biophysical Research Communications, 425(2), 393-397. https://dx.doi.org/10.1016/j.bbrc.2012.07.108
MLA:
Klein, Stefanie, et al. "Superparamagnetic iron oxide nanoparticles as radiosensitizer via enhanced reactive oxygen species formation." Biochemical and Biophysical Research Communications 425.2 (2012): 393-397.
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