Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

Journal article


Publication Details

Author(s): Munoz LE, Bilyy R, Biermann MHC, Kienhoefer D, Maueröder C, Hahn J, Brauner JM, Weidner D, Chen J, Scharin-Mehlmann M, Janko C, Friedrich RP, Mielenz D, Dumych T, Lootsik MD, Schauer C, Schett G, Hoffmann M, Zhao Y, Herrmann M
Journal: Proceedings of the National Academy of Sciences of the United States of America
Publication year: 2016
Volume: 113
Journal issue: 40
Pages range: E5856-E5865
ISSN: 0027-8424
eISSN: 1091-6490


Abstract


The critical size for strong interaction of hydrophobic particles with phospholipid bilayers has been predicted to be 10 nm. Because of the wide spreading of nonpolar nanoparticles (NPs) in the environment, we aimed to reveal the ability of living organisms to entrap NPs via formation of neutrophil extracellular traps (NETs). Upon interaction with various cell types and tissues, 10- to 40-nm-sized NPs induce fast (<20 min) damage of plasma membranes and instability of the lysosomal compartment, leading to the immediate formation of NETs. In contrast, particles sized 100-1,000 nm behaved rather inertly. Resulting NET formation (NETosis) was accompanied by an inflammatory reaction intrinsically endowed with its own resolution, demonstrated in lungs and air pouches of mice. Persistence of small NPs in joints caused unremitting arthritis and bone remodeling. Small NPs coinjected with antigen exerted adjuvant-like activity. This report demonstrates a cellular mechanism that explains how small NPs activate the NETosis pathway and drive their entrapping and resolution of the initial inflammatory response.



FAU Authors / FAU Editors

Chen, Juan
Lehrstuhl für Neurochirurgie
Hahn, Jonas
Medizinische Klinik 3 - Rheumatologie und Immunologie
Herrmann, Martin Prof. Dr.
Medizinische Klinik 3 - Rheumatologie und Immunologie
Medizinische Klinik 3 - Rheumatologie und Immunologie
Maueröder, Christian
Medizinische Klinik 3 - Rheumatologie und Immunologie
Mielenz, Dirk Prof. Dr.
Medizinische Fakultät
Scharin-Mehlmann, Marina
Lehrstuhl für Elektronische Bauelemente
Schett, Georg Prof. Dr. med.
Lehrstuhl für Innere Medizin III


Additional Organisation
Exzellenz-Cluster Engineering of Advanced Materials


External institutions with authors

Danylo Halytsky Lviv National Medical University / Львiвський Національний Медичний Унiверситет iм. Данила Галицького


Research Fields

Nanosafety
Exzellenz-Cluster Engineering of Advanced Materials


How to cite

APA:
Munoz, L.E., Bilyy, R., Biermann, M.H.C., Kienhoefer, D., Maueröder, C., Hahn, J.,... Herrmann, M. (2016). Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation. Proceedings of the National Academy of Sciences of the United States of America, 113(40), E5856-E5865. https://dx.doi.org/10.1073/pnas.1602230113

MLA:
Munoz, Luis E., et al. "Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation." Proceedings of the National Academy of Sciences of the United States of America 113.40 (2016): E5856-E5865.

BibTeX: 

Last updated on 2019-06-08 at 09:02