Clinico-pathological subtypes of hippocampal sclerosis in temporal lobe epilepsy and their differential impact on memory impairment

Coras R, Blümcke I (2015)


Publication Type: Journal article

Publication year: 2015

Journal

Book Volume: 309

Pages Range: 153-61

DOI: 10.1016/j.neuroscience.2015.08.003

Abstract

Hippocampal anatomy and network organization are capable to generate drug-resistant temporal lobe epilepsy (TLE) in humans and particularly vulnerable to segmental neuronal cell loss. Surgical hippocampectomy has been proven successful in treatment and available human tissue specimens allow systematic clinico-pathological examination. Different patterns of hippocampal cell loss have been identified in TLE patients and are recently classified by the International League against Epilepsy (ILAE) into four distinct subtypes in order to stratify the heterogenous group of TLE patients also with respect to postsurgical outcome. Another important aim of the international consensus classification system of hippocampal sclerosis (HS) is to gain further insights into the morpho-functional organization of human memory frequently compromised in TLE patients.

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How to cite

APA:

Coras, R., & Blümcke, I. (2015). Clinico-pathological subtypes of hippocampal sclerosis in temporal lobe epilepsy and their differential impact on memory impairment. Neuroscience, 309, 153-61. https://doi.org/10.1016/j.neuroscience.2015.08.003

MLA:

Coras, R., and Ingmar Blümcke. "Clinico-pathological subtypes of hippocampal sclerosis in temporal lobe epilepsy and their differential impact on memory impairment." Neuroscience 309 (2015): 153-61.

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