Multifunctional Chitosan-45S5 Bioactive Glass-Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Microsphere Composite Membranes for Guided Tissue/Bone Regeneration

Journal article
(Original article)


Publication Details

Author(s): Li W, Ding Y, Yu S, Yao Q, Boccaccini AR
Journal: ACS Applied Materials and Interfaces
Publication year: 2015
Volume: 7
Journal issue: 37
Pages range: 20845-20854
ISSN: 1944-8244
eISSN: 1944-8252


Abstract


Novel multifunctional chitosan-45S5 bioactive glass-poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microsphere (CS-BG-MS) composite membranes were developed with applicability in guided tissue/bone regeneration (GTR/GBR). The incorporation of 45S5 BG and PHBV MS into CS membranes not only provided the membranes with favorable surface roughness, hydrophilicity, and flexibility but also slowed down their degradation rate. Moreover, the CS membranes became bioactive after the incorporation of 45S5 BG and capable of releasing drugs of different physicochemical properties in a controlled and sustained manner with the addition of PHBV MS. Cell culture tests showed that osteoblast-like MG-63 human osteosarcoma cells had significantly higher adhesion, cell proliferation, and alkaline phosphatase (ALP) activity on CS-BG and CS-BG-MS membranes than on neat CS membranes. Therefore, the developed bioactive CS-BG-MS membranes with potential multidrug (e.g., antibacterial and antiosteoporosis drugs) delivery capability are promising candidate membranes for GTR/GBR applications.



FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Ding, Yaping
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Li, Wei
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)


External institutions with authors

Wenzhou Medical University / 温州医科大学 (WMU)


How to cite

APA:
Li, W., Ding, Y., Yu, S., Yao, Q., & Boccaccini, A.R. (2015). Multifunctional Chitosan-45S5 Bioactive Glass-Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Microsphere Composite Membranes for Guided Tissue/Bone Regeneration. ACS Applied Materials and Interfaces, 7(37), 20845-20854. https://dx.doi.org/10.1021/acsami.5b06128

MLA:
Li, Wei, et al. "Multifunctional Chitosan-45S5 Bioactive Glass-Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Microsphere Composite Membranes for Guided Tissue/Bone Regeneration." ACS Applied Materials and Interfaces 7.37 (2015): 20845-20854.

BibTeX: 

Last updated on 2019-15-05 at 10:33