Use of probe-based confocal laser endomicroscopy (pCLE) in gastrointestinal applications. A consensus report based on clinical evidence

Wang KK, Carr-Locke DL, Singh SK, Neumann H, Bertani H, Galmiche JP, Arsenescu RI, Caillol F, Chang KJ, Chaussade S, Coron E, Costamagna G, Dlugosz A, Gan SI, Giovannini M, Gress FG, Haluszka O, Ho KY, Kahaleh M, Konda VJ, Prat F, Shah RJ, Sharma P, Slivka A, Wolfsen HC, Zfass A (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Book Volume: 3

Pages Range: 230-54

Journal Issue: 3

DOI: 10.1177/2050640614566066

Abstract

Probe-based confocal laser endomicroscopy (pCLE) provides microscopic imaging during an endoscopic procedure. Its introduction as a standard modality in gastroenterology has brought significant progress in management strategies, affecting many aspects of clinical care and requiring standardisation of practice and training.This study aimed to provide guidance on the standardisation of its practice and training in Barrett's oesophagus, biliary strictures, colorectal lesions and inflammatory bowel diseases.Initial statements were developed by five group leaders, based on the available clinical evidence. These statements were then voted and edited by the 26 participants, using a modified Delphi approach. After two rounds of votes, statements were validated if the threshold of agreement was higher than 75%.Twenty-six experts participated and, among a total of 77 statements, 61 were adopted (79%) and 16 were rejected (21%). The adoption of each statement was justified by the grade of evidence.pCLE should be used to enhance the diagnostic arsenal in the evaluation of these indications, by providing microscopic information which improves the diagnostic performance of the physician. In order actually to implement this technology in the clinical routine, and to ensure good practice, standardised initial and continuing institutional training programmes should be established.

Involved external institutions

Virginia Commonwealth University (VCU) United States (USA) (US) Mayo Clinic United States (USA) (US) University of Pittsburgh United States (USA) (US) Veterans Affairs Medical Center Kansas City United States (USA) (US) University of Colorado System United States (USA) (US) Hôpital Cochin France (FR) University of Chicago Medical Center United States (USA) (US) Cornell University United States (USA) (US) National University of Singapore (NUS) Singapore (SG) Temple University United States (USA) (US) Columbia University United States (USA) (US) Institute Paoli-Calmettes France (FR) Virginia Mason Medical Center United States (USA) (US) Karolinska Institute Sweden (SE) Catholic University of the Sacred Heart / Università Cattolica del Sacro Cuore Italy (IT) Nantes University Hospital / Centre hospitalier universitaire de Nantes (CHU) France (FR) University of California Irvine United States (USA) (US) Ohio State University United States (USA) (US) Nuovo Ospedale Civile S. Agostino-Estense Italy (IT) Boston University United States (USA) (US) Beth Israel Deaconess Medical Center (BIDMC) United States (USA) (US)

How to cite

APA:

Wang, K.K., Carr-Locke, D.L., Singh, S.K., Neumann, H., Bertani, H., Galmiche, J.-P.,... Zfass, A. (2015). Use of probe-based confocal laser endomicroscopy (pCLE) in gastrointestinal applications. A consensus report based on clinical evidence. United European Gastroenterology Journal, 3(3), 230-54. https://dx.doi.org/10.1177/2050640614566066

MLA:

Wang, Kenneth K., et al. "Use of probe-based confocal laser endomicroscopy (pCLE) in gastrointestinal applications. A consensus report based on clinical evidence." United European Gastroenterology Journal 3.3 (2015): 230-54.

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