In vitro endothelial cell response to ionic dissolution products from boron-doped bioactive glass in the SiO2-CaO-P2O5-Na2O system

Durand LAH, Gongora A, Lopez JMP, Boccaccini AR, Zago MP, Baldi A, Gorustovich A (2014)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2014

Journal

Journal of Materials Chemistry B Royal Society of Chemistry

Book Volume: 2

Pages Range: 7620-7630

Journal Issue: 43

DOI: 10.1039/c4tb01043d

Abstract

As it has been established that boron (B) may perform functions in angiogenesis and osteogenesis, the controlled and localized release of B ions from bioactive glasses (BGs) is expected to provide a promising therapeutic alternative for regenerative medicine of vascularized tissues, such as bone. The aim of this study was to assess the in vitro angiogenic effects of the ionic dissolution products (IDPs) from BGs in the SiO-CaO-NaO-PO (45S5) system and of those from 45S5 BG doped with 2 wt% BO (45S5.2B). The results show, for the first time, the IDPs from 45S5.2B BG stimulated human umbilical vein endothelial cell (HUVEC) proliferation and migration that were associated with phosphorylation of extracellular signal-related kinase (ERK) 1/2, focal adhesion kinase (FAK) and p38 protein. It was also shown that IDPs from 45S5.2B BG could enhance in vitro HUVEC tubule formation and secretion of interleukin 6 (IL6) and the basic fibroblast growth factor (bFGF). The effects observed are attributed to the presence of B in the IDPs. These findings are relevant to bone tissue engineering and regeneration because the IDPs from 45S5.2B BG may act as inexpensive inorganic angiogenic agents providing a convenient alternative to the application of conventional angiogenic growth factors.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) / National Scientific and Technical Research Council AR Argentina (AR)

How to cite

APA:

Durand, L.A.H., Gongora, A., Lopez, J.M.P., Boccaccini, A.R., Zago, M.P., Baldi, A., & Gorustovich, A. (2014). In vitro endothelial cell response to ionic dissolution products from boron-doped bioactive glass in the SiO2-CaO-P2O5-Na2O system. Journal of Materials Chemistry B, 2(43), 7620-7630. https://dx.doi.org/10.1039/c4tb01043d

MLA:

Durand, Luis A. Haro, et al. "In vitro endothelial cell response to ionic dissolution products from boron-doped bioactive glass in the SiO2-CaO-P2O5-Na2O system." Journal of Materials Chemistry B 2.43 (2014): 7620-7630.

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