Alginate-based hydrogels with improved adhesive properties for cell encapsulation

Journal article
(Original article)


Publication Details

Author(s): Sarker B, Rompf J, Silva R, Lang N, Detsch R, Kaschta J, Fabry B, Boccaccini AR
Journal: International Journal of Biological Macromolecules
Publication year: 2015
Volume: 78
Pages range: 72-78
ISSN: 1879-0003


Abstract


Hydrogel-based biomaterials are ideal scaffolding matrices for microencapsulation, but they need to be modified to resemble the mechanical, structural and chemical properties of the native extracellular matrix. Here, we compare the mechanical properties and the degradation behavior of unmodified and modified alginate hydrogels in which cell adhesive functionality is conferred either by blending or covalently cross-linking with gelatin. Furthermore, we measure the spreading and proliferation of encapsulated osteoblast-like MG-63 cells. Alginate hydrogels covalently crosslinked with gelatin show the highest degree of cell adhesion, spreading, migration, and proliferation, as well as a faster degradation rate, and are therefore a particularly suitable material for microencapsulation.



FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Detsch, Rainer Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Fabry, Ben Prof. Dr.
Lehrstuhl für Biophysik
Kaschta, Joachim Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Lang, Nadine
Lehrstuhl für Biophysik
Sarker, Bapi
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)


How to cite

APA:
Sarker, B., Rompf, J., Silva, R., Lang, N., Detsch, R., Kaschta, J.,... Boccaccini, A.R. (2015). Alginate-based hydrogels with improved adhesive properties for cell encapsulation. International Journal of Biological Macromolecules, 78, 72-78. https://dx.doi.org/10.1016/j.ijbiomac.2015.03.061

MLA:
Sarker, Bapi, et al. "Alginate-based hydrogels with improved adhesive properties for cell encapsulation." International Journal of Biological Macromolecules 78 (2015): 72-78.

BibTeX: 

Last updated on 2019-06-04 at 14:50