Comparative sensitizing potencies of fragrances, preservatives, and hair dyes
Liden C, Yazar K, Johansen JD, Karlberg AT, Uter W, White IR (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 75
Pages Range: 265-275
Journal Issue: 5
DOI: 10.1111/cod.12683
Abstract
The local lymph node assay (LLNA) is used for assessing sensitizing potential in hazard identification and risk assessment for regulatory purposes. Sensitizing potency on the basis of the LLNA is categorized into extreme (EC3 value of <=0.2%), strong (>0.2% to <=2%), and moderate (>2%). To compare the sensitizing potencies of fragrance substances, preservatives, and hair dye substances, which are skin sensitizers that frequently come into contact with the skin of consumers and workers, LLNA results and EC3 values for 72 fragrance substances, 25 preservatives and 107 hair dye substances were obtained from two published compilations of LLNA data and opinions by the Scientific Committee on Consumer Safety and its predecessors. The median EC3 values of fragrances (n = 61), preservatives (n = 19) and hair dyes (n = 59) were 5.9%, 0.9%, and 1.3%, respectively. The majority of sensitizing preservatives and hair dyes are thus strong or extreme sensitizers (EC3 value of <=2%), and fragrances are mostly moderate sensitizers. Although fragrances are typically moderate sensitizers, they are among the most frequent causes of contact allergy. This indicates that factors other than potency need to be addressed more rigorously in risk assessment and risk management.
Authors with CRIS profile
Involved external institutions
Guy's and St Thomas' (NHS Foundation Trust)
United Kingdom (GB)
University of Gothenburg / Göteborgs universitet
Sweden (SE)
University of Copenhagen
Denmark (DK)
Karolinska Institute
Sweden (SE)
United Kingdom (GB)
University of Gothenburg / Göteborgs universitet
Sweden (SE)
University of Copenhagen
Denmark (DK)
Karolinska Institute
Sweden (SE)
How to cite
APA:
Liden, C., Yazar, K., Johansen, J.D., Karlberg, A.-T., Uter, W., & White, I.R. (2016). Comparative sensitizing potencies of fragrances, preservatives, and hair dyes. Contact Dermatitis, 75(5), 265-275. https://dx.doi.org/10.1111/cod.12683
MLA:
Liden, Carola, et al. "Comparative sensitizing potencies of fragrances, preservatives, and hair dyes." Contact Dermatitis 75.5 (2016): 265-275.
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