Böckmann R (2003)
Publication Language: English
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2003
Publisher: Elsevier (Cell Press) / Biophysical Society
Book Volume: 85
Pages Range: 1647-55
Volume: 85
Issue: 3
Journal Issue: 3
DOI: 10.1016/S0006-3495(03)74594-9
Electrostatic interactions govern structural and dynamical properties of membranes and can vary considerably with the composition of the aqueous buffer. We studied the influence of sodium chloride on a pure POPC lipid bilayer by fluorescence correlation spectroscopy experiments and molecular dynamics simulations. Increasing sodium chloride concentration was found to decrease the self-diffusion of POPC lipids within the bilayer. Self-diffusion coefficients calculated from the 100 ns simulations agree with those measured on a millisecond timescale, suggesting that most of the relaxation processes relevant for lipid diffusion are faster than the simulation timescale. As the dominant effect, the molecular dynamics simulations revealed a tight binding of sodium ions to the carbonyl oxygens of on average three lipids leading to larger complexes with reduced mobility. Additionally, the bilayer thickens by approximately 2 A, which increases the order parameter of the fatty acyl chains. Sodium binding alters the electrostatic potential, which is largely compensated by a changed polarization of the aqueous medium and a lipid dipole reorientation.
APA:
Böckmann, R. (2003). Effect of sodium chloride on a lipid bilayer. Biophysical Journal, 85(3), 1647-55. https://doi.org/10.1016/S0006-3495(03)74594-9
MLA:
Böckmann, Rainer. "Effect of sodium chloride on a lipid bilayer." Biophysical Journal 85.3 (2003): 1647-55.
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