Morphological alterations within the peripheral fixation of the iris dilator muscle in eyes with pigmentary glaucoma

Journal article


Publication Details

Author(s): Flügel-Koch C, Tektas OY, Kaufman PL, Paulsen F, Lütjen-Drecoll E
Journal: Investigative Ophthalmology & Visual Science
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
Publication year: 2014
Volume: 55
Journal issue: 7
Pages range: 4541-51
ISSN: 0146-0404


Abstract


To analyze the peripheral fixation of the iris dilator muscle in normal eyes and in eyes with pigmentary glaucoma (PG).Using 63 control eyes (age 18 months-99 years), the peripheral iris dilator was investigated by light microscopy, immunohistochemistry, and electron microscopy. Development was studied using 18 differently aged fetal eyes stained immunohistochemically against ?-smooth muscle (SM) actin. The peripheral iris dilator muscle in PG was analyzed using semithin and ultrathin sections of six glutaraldehyde-fixed eyes from three donors aged 38, 62, and 74 years.In normal eyes, the peripheral end of the iris dilator muscle is arranged in a sphincter-like manner. Arcade-shaped tendinous connections associated with myofibroblasts (iridial strands) anchor the iris dilator within the elastic-fibromuscular ciliary meshwork that also serves as fixation area for the elastic tendons of the inner ciliary muscle portions. The iridial strands are innervated and can adapt their length during accommodation. The PG eyes show incomplete circular bundles and iridial strands that are mainly anchored to the iris stroma and the flexible uveal parts of the trabecular meshwork.The normal anchorage of the peripheral iris dilator and its presumably neuronally regulated length adaptation stabilize the peripheral iris during accommodation. Insufficient fixation in PG could promote posterior bowing of the iris with rubbing against the zonular fibers and pigment liberation from the iris pigmented epithelium.



FAU Authors / FAU Editors

Flügel-Koch, Cassandra Prof. Dr.
Medizinische Fakultät
Lütjen-Drecoll, Elke Prof. Dr.
Tektas, Ozan Yüksel Dr. med.
Medizinische Fakultät
Paulsen, Friedrich Prof. Dr.
Lehrstuhl für Anatomie II
Lehrstuhl für Anatomie II


External institutions with authors

University of Wisconsin - Madison


How to cite

APA:
Flügel-Koch, C., Tektas, O.Y., Kaufman, P.L., Paulsen, F., & Lütjen-Drecoll, E. (2014). Morphological alterations within the peripheral fixation of the iris dilator muscle in eyes with pigmentary glaucoma. Investigative Ophthalmology & Visual Science, 55(7), 4541-51. https://dx.doi.org/10.1167/iovs.13-13765

MLA:
Flügel-Koch, Cassandra, et al. "Morphological alterations within the peripheral fixation of the iris dilator muscle in eyes with pigmentary glaucoma." Investigative Ophthalmology & Visual Science 55.7 (2014): 4541-51.

BibTeX: 

Last updated on 2018-08-10 at 03:02