Intensified pharmaceutical care is improving immunosuppressive medication adherence in kidney transplant recipients during the first post-transplant year: a quasi-experimental study

Journal article


Publication Details

Author(s): Joost R, Dörje F, Schwitulla J, Eckardt KU, Hugo C
Journal: Nephrology Dialysis Transplantation
Publisher: Oxford University Press (OUP): Policy B
Publication year: 2014
Volume: 29
Journal issue: 8
Pages range: 1597-607
ISSN: 0931-0509


Abstract


Medication adherence is critical for transplant patients because the consequences of non-adherence can result in allograft loss and may be life threatening.A prospective study with 74 renal transplant recipients using a sequential control group design was performed to investigate the impact of a pharmaceutical intensified care programme led by a clinical pharmacist on daily drug adherence during the first year after renal transplantation. Thirty-nine patients of the control group received the already established standardized drug and transplant training, while 35 patients of the intensified care group (ICG) received additional inpatient and outpatient pharmaceutical care and counselling by a dedicated clinical pharmacist. Applied interventions were clustered and classified using the behaviour change technique taxonomy according to Michie. Adherence to immunosuppressive drug therapy was monitored up to 1 year using a medication event monitoring system, pill count (PC), drug holiday (DH) occurrence, Morisky questionnaire and self-report.Sixty-seven patients (35 of the standard care and 32 of the ICG) were analysed. Implementation of DA was significantly (P = 0.014) improved in patients of the ICG (91%) compared with SCG (75%) during the first year after transplantion. Daily adherence measures were already improved within 30-40 days after start of intensified patient care and continued throughout the study period. Intensified care patients also showed significantly better results for taking adherence (P = 0.006), PC (P = 0.008) and DHs (P = 0.001).The additional, intensified pharmaceutical care improved patients' medication adherence remarkably, suggesting that the applied additional care programme has the potential to improve outcomes after organ transplantation.



FAU Authors / FAU Editors

Dörje, Frank Prof. Dr.
Lehrstuhl für Pharmazeutische Technologie
Eckardt, Kai-Uwe Prof. Dr. med.
Lehrstuhl für Innere Medizin IV
Joost, Robert
Professur für Innere Medizin (Nephrologie und Hypertensiologie)
Schwitulla, Judith
Frauenklinik


External institutions with authors

Universitätsklinikum Carl Gustav Carus Dresden


How to cite

APA:
Joost, R., Dörje, F., Schwitulla, J., Eckardt, K.-U., & Hugo, C. (2014). Intensified pharmaceutical care is improving immunosuppressive medication adherence in kidney transplant recipients during the first post-transplant year: a quasi-experimental study. Nephrology Dialysis Transplantation, 29(8), 1597-607. https://dx.doi.org/10.1093/ndt/gfu207

MLA:
Joost, Robert, et al. "Intensified pharmaceutical care is improving immunosuppressive medication adherence in kidney transplant recipients during the first post-transplant year: a quasi-experimental study." Nephrology Dialysis Transplantation 29.8 (2014): 1597-607.

BibTeX: 

Last updated on 2018-08-10 at 03:02