Evidence of innate lymphoid cell redundancy in humans

Vely F, Barlogis V, Vallentin B, Neven B, Piperoglou C, Perchet T, Petit M, Yessaad N, Touzot F, Bruneau J, Mahlaoui N, Zucchini N, Farnarier C, Michel G, Moshous D, Blanche S, Dujardin A, Spits H, Distler J, Picard C, Golub R, Fischer A, Vivier E, Ramming A (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Nature Immunology Nature Research

Book Volume: 17

Pages Range: 1291-1299

Journal Issue: 11

DOI: 10.1038/ni.3553

Abstract

Innate lymphoid cells (ILCs) have potent immunological functions in experimental conditions in mice, but their contributions to immunity in natural conditions in humans have remained unclear. We investigated the presence of ILCs in a cohort of patients with severe combined immunodeficiency (SCID). All ILC subsets were absent in patients with SCID who had mutation of the gene encoding the common ?-chain cytokine receptor subunit IL-2R? or the gene encoding the tyrosine kinase JAK3. T cell reconstitution was observed in patients with SCID after hematopoietic stem cell transplantation (HSCT), but the patients still had considerably fewer ILCs in the absence of myeloablation than did healthy control subjects, with the exception of rare cases of reconstitution of the ILC1 subset of ILCs. Notably, the ILC deficiencies observed were not associated with any particular susceptibility to disease, with follow-up extending from 7 years to 39 years after HSCT. We thus report here selective ILC deficiency in humans and show that ILCs might be dispensable in natural conditions, if T cells are present and B cell function is preserved.

Authors with CRIS profile

Jörg Distler Professur für Molekulare Mechanismen der Organfibrose Andreas Ramming Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

University of Amsterdam NL Netherlands (NL) Aix-Marseille University / Aix-Marseille Université FR France (FR) Hôpital de la Timone FR France (FR) Hôpital Necker-Enfants malades FR France (FR) National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM) FR France (FR) University of Paris 5 - René Descartes / Université Paris V René Descartes FR France (FR) BD FR France (FR) Hôpital de la Conception FR France (FR) Innate Pharma SA FR France (FR)

How to cite

APA:

Vely, F., Barlogis, V., Vallentin, B., Neven, B., Piperoglou, C., Perchet, T.,... Ramming, A. (2016). Evidence of innate lymphoid cell redundancy in humans. Nature Immunology, 17(11), 1291-1299. https://doi.org/10.1038/ni.3553

MLA:

Vely, Frederic, et al. "Evidence of innate lymphoid cell redundancy in humans." Nature Immunology 17.11 (2016): 1291-1299.

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