Novel therapeutic strategies for cardioprotection

Journal article


Publication Details

Author(s): Sluijter JPG, Condorelli G, Davidson SM, Engel F, Ferdinandy P, Hausenloy DJ, Lecour S, Madonna R, Ovize M, Ruiz-Meana M, Schulz R, Van Laake LW
Journal: Pharmacology & Therapeutics
Publisher: Elsevier
Publication year: 2014
Volume: 144
Journal issue: 1
Pages range: 60-70
ISSN: 0163-7258


Abstract


The morbidity and mortality from ischemic heart disease (IHD) remain significant worldwide. The treatment for acute myocardial infarction has improved over the past decades, including early reperfusion of occluded coronary arteries. Although it is essential to re-open the artery as soon as possible, paradoxically this leads to additional myocardial injury, called acute ischemia-reperfusion injury (IRI), for which currently no effective therapy is available. Therefore, novel therapeutic strategies are required to protect the heart from acute IRI in order to reduce myocardial infarction size, preserve cardiac function and improve clinical outcomes in patients with IHD. In this review article, we will first outline the pathophysiology of acute IRI and review promising therapeutic strategies for cardioprotection. These include novel aspects of mitochondrial function, epigenetics, circadian clocks, the immune system, microvesicles, growth factors, stem cell therapy and gene therapy. We discuss the therapeutic potential of these novel cardioprotective strategies in terms of pharmacological targeting and clinical application.



FAU Authors / FAU Editors

Engel, Felix Prof. Dr. rer. nat.
Professur für Experimentelle Nieren- und Kreislaufforschung


External institutions with authors

Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona
Hopital Louis Pradel
Justus-Liebig-Universität Gießen
Semmelweis University
Università degli studi di Milano
Università degli Studi Gabriele D'Annunzio
University College London (UCL)
University Medical Centre Utrecht (UMC Utrecht)
University of Cape Town (UCT)


How to cite

APA:
Sluijter, J.P.G., Condorelli, G., Davidson, S.M., Engel, F., Ferdinandy, P., Hausenloy, D.J.,... Van Laake, L.W. (2014). Novel therapeutic strategies for cardioprotection. Pharmacology & Therapeutics, 144(1), 60-70. https://dx.doi.org/10.1016/j.pharmthera.2014.05.005

MLA:
Sluijter, Joost P. G., et al. "Novel therapeutic strategies for cardioprotection." Pharmacology & Therapeutics 144.1 (2014): 60-70.

BibTeX: 

Last updated on 2018-08-10 at 02:56