Novel therapeutic strategies for cardioprotection
Sluijter JPG, Condorelli G, Davidson SM, Engel F, Ferdinandy P, Hausenloy DJ, Lecour S, Madonna R, Ovize M, Ruiz-Meana M, Schulz R, Van Laake LW (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Publisher: Elsevier
Book Volume: 144
Pages Range: 60-70
Journal Issue: 1
DOI: 10.1016/j.pharmthera.2014.05.005
Abstract
The morbidity and mortality from ischemic heart disease (IHD) remain significant worldwide. The treatment for acute myocardial infarction has improved over the past decades, including early reperfusion of occluded coronary arteries. Although it is essential to re-open the artery as soon as possible, paradoxically this leads to additional myocardial injury, called acute ischemia-reperfusion injury (IRI), for which currently no effective therapy is available. Therefore, novel therapeutic strategies are required to protect the heart from acute IRI in order to reduce myocardial infarction size, preserve cardiac function and improve clinical outcomes in patients with IHD. In this review article, we will first outline the pathophysiology of acute IRI and review promising therapeutic strategies for cardioprotection. These include novel aspects of mitochondrial function, epigenetics, circadian clocks, the immune system, microvesicles, growth factors, stem cell therapy and gene therapy. We discuss the therapeutic potential of these novel cardioprotective strategies in terms of pharmacological targeting and clinical application.
Authors with CRIS profile
Involved external institutions
University Medical Centre Utrecht (UMC Utrecht)
Netherlands (NL)
Università degli studi di Milano
Italy (IT)
University College London (UCL)
United Kingdom (GB)
Semmelweis University / Semmelweis Egyetem
Hungary (HU)
University of Cape Town (UCT)
South Africa (ZA)
Università degli Studi Gabriele D'Annunzio
Italy (IT)
Hopital Louis Pradel
France (FR)
Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona
Spain (ES)
Justus-Liebig-Universität Gießen
Germany (DE)
Netherlands (NL)
Università degli studi di Milano
Italy (IT)
University College London (UCL)
United Kingdom (GB)
Semmelweis University / Semmelweis Egyetem
Hungary (HU)
University of Cape Town (UCT)
South Africa (ZA)
Università degli Studi Gabriele D'Annunzio
Italy (IT)
Hopital Louis Pradel
France (FR)
Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona
Spain (ES)
Justus-Liebig-Universität Gießen
Germany (DE)
How to cite
APA:
Sluijter, J.P.G., Condorelli, G., Davidson, S.M., Engel, F., Ferdinandy, P., Hausenloy, D.J.,... Van Laake, L.W. (2014). Novel therapeutic strategies for cardioprotection. Pharmacology & Therapeutics, 144(1), 60-70. https://doi.org/10.1016/j.pharmthera.2014.05.005
MLA:
Sluijter, Joost P. G., et al. "Novel therapeutic strategies for cardioprotection." Pharmacology & Therapeutics 144.1 (2014): 60-70.
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