The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: advancing clinical research in subarachnoid hemorrhage
Jaja BNR, Attalla D, Macdonald RL, Schweizer TA, Cusimano MD, Etminan N, Hanggi D, Hasan D, Johnston SC, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Noble A, Quinn A, Schenk T, Spears J, Singh J, Todd M, Torner J, Tseng M, Van Den Bergh W, Vergouwen MDI, Wong GKC (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Publisher: Humana Press
Book Volume: 21
Pages Range: 551-9
Journal Issue: 3
DOI: 10.1007/s12028-014-9990-y
Abstract
Researchers and other stakeholders continue to express concern about the failure of randomized clinical trials (RCT) in subarachnoid hemorrhage (SAH) to show efficacy of new treatments. Pooled data may be particularly useful to generate hypotheses about causes of poor outcomes and reasons for failure of RCT in SAH, and strategies to improve them. Investigators conducting SAH research collaborated to share data with the intent to develop a large repository of pooled individual patient data for exploratory analysis and testing of new hypotheses relevant to improved trial design and analysis in SAH. This repository currently contains information on 11,443 SAH patients from 14 clinical databases, of which 9 are datasets of recent RCTs and 5 are datasets of prospective observational studies and hospital registries. Most patients were managed in the last 15 years. Data validation and quality checks have been conducted and are satisfactory. Data is available on demographic, clinical, neuroimaging, and laboratory results and various outcome measures. We have compiled the largest known dataset of patients with SAH. The SAHIT repository may be an important resource for advancing clinical research in SAH and will benefit from contributions of additional datasets.
Authors with CRIS profile
Involved external institutions
University of Toronto
Canada (CA)
Heinrich-Heine-Universität Düsseldorf
Germany (DE)
University of Iowa
United States (USA) (US)
University of California San Francisco (UCSF)
United States (USA) (US)
Thomas Jefferson University
United States (USA) (US)
Columbia University
United States (USA) (US)
University of Oxford
United Kingdom (GB)
King’s College London
United Kingdom (GB)
Leeds General Infirmary
United Kingdom (GB)
Medicines and Healthcare products Regulatory Agency
United Kingdom (GB)
University of Groningen / Rijksuniversiteit Groningen
Netherlands (NL)
University Medical Centre Utrecht (UMC Utrecht)
Netherlands (NL)
The Chinese University of Hong Kong (CUHK)
China (CN)
Canada (CA)
Heinrich-Heine-Universität Düsseldorf
Germany (DE)
University of Iowa
United States (USA) (US)
University of California San Francisco (UCSF)
United States (USA) (US)
Thomas Jefferson University
United States (USA) (US)
Columbia University
United States (USA) (US)
University of Oxford
United Kingdom (GB)
King’s College London
United Kingdom (GB)
Leeds General Infirmary
United Kingdom (GB)
Medicines and Healthcare products Regulatory Agency
United Kingdom (GB)
University of Groningen / Rijksuniversiteit Groningen
Netherlands (NL)
University Medical Centre Utrecht (UMC Utrecht)
Netherlands (NL)
The Chinese University of Hong Kong (CUHK)
China (CN)
How to cite
APA:
Jaja, B.N.R., Attalla, D., Macdonald, R.L., Schweizer, T.A., Cusimano, M.D., Etminan, N.,... Wong, G.K.C. (2014). The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: advancing clinical research in subarachnoid hemorrhage. Neurocritical Care, 21(3), 551-9. https://doi.org/10.1007/s12028-014-9990-y
MLA:
Jaja, Blessing N. R., et al. "The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: advancing clinical research in subarachnoid hemorrhage." Neurocritical Care 21.3 (2014): 551-9.
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