The ceramide system as a novel antidepressant target
Kornhuber J, Müller C, Becker KA, Reichel M, Gulbins E (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Publisher: Elsevier
Book Volume: 35
Pages Range: 293-304
Journal Issue: 6
DOI: 10.1016/j.tips.2014.04.003
Abstract
Major depression is a systems disorder which impairs not only central nervous system aspects of mood and behavior but also peripheral organ systems. Current views on the pathogenesis and treatment of depression are predominantly based on proteins and transmitters and thus are difficult to reconcile central with peripheral pathomechanisms. Recent research showed that there is also a lipid-based pathway involved in the pathology of depression, which is activated by psychosocial stress, oxidative stress, or inflammation. Inducible dysfunction of the ceramide pathway, which is abundant in the brain as well as in peripheral organs, may account for mood disorder, behavioral symptoms, and further promote inflammation and oxidative stress in peripheral systems. As such, the lipid ceramide pathway may provide the missing link between brain dysfunction and somatic symptoms of depression. Pharmacological interventions that reduce ceramide abundance also show antidepressant action and may promise a better treatment of major depression.
Authors with CRIS profile
Johannes Kornhuber
Lehrstuhl für Psychiatrie und Psychotherapie
Christiane Müller
Medizinische Fakultät
Martin Reichel
Department of Psychiatry and Psychotherapy
Involved external institutions
Germany (DE)How to cite
APA:
Kornhuber, J., Müller, C., Becker, K.A., Reichel, M., & Gulbins, E. (2014). The ceramide system as a novel antidepressant target. Trends in Pharmacological Sciences, 35(6), 293-304. https://doi.org/10.1016/j.tips.2014.04.003
MLA:
Kornhuber, Johannes, et al. "The ceramide system as a novel antidepressant target." Trends in Pharmacological Sciences 35.6 (2014): 293-304.
BibTeX: Download