Misaka S, Yatabe J, Müller F, Takano K, Kawabe K, Gläser H, Yatabe MS, Onoue S, Werba JP, Watanabe H, Yamada S, Fromm M, Kimura J (2014)
Publication Type: Journal article
Publication year: 2014
Publisher: American Society for Clinical Pharmacology and Therapeutics
Book Volume: 95
Pages Range: 432-8
Journal Issue: 4
This study aimed to evaluate the effects of green tea on the pharmacokinetics and pharmacodynamics of the ?-blocker nadolol. Ten healthy volunteers received a single oral dose of 30 mg nadolol with green tea or water after repeated consumption of green tea (700 ml/day) or water for 14 days. Catechin concentrations in green tea and plasma were determined. Green tea markedly decreased the maximum plasma concentration (Cmax) and area under the plasma concentration-time curve (AUC0-48) of nadolol by 85.3% and 85.0%, respectively (P < 0.01), without altering renal clearance of nadolol. The effects of nadolol on systolic blood pressure were significantly reduced by green tea. [(3)H]-Nadolol uptake assays in human embryonic kidney 293 cells stably expressing the organic anion-transporting polypeptides OATP1A2 and OATP2B1 revealed that nadolol is a substrate of OATP1A2 (Michaelis constant (Km) = 84.3 ?mol/l) but not of OATP2B1. Moreover, green tea significantly inhibited OATP1A2-mediated nadolol uptake (half-maximal inhibitory concentration, IC50 = 1.36%). These results suggest that green tea reduces plasma concentrations of nadolol possibly in part by inhibition of OATP1A2-mediated uptake of nadolol in the intestine.
APA:
Misaka, S., Yatabe, J., Müller, F., Takano, K., Kawabe, K., Gläser, H.,... Kimura, J. (2014). Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. Clinical Pharmacology & Therapeutics, 95(4), 432-8. https://doi.org/10.1038/clpt.2013.241
MLA:
Misaka, S., et al. "Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects." Clinical Pharmacology & Therapeutics 95.4 (2014): 432-8.
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