Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules

Meyer zu Hörste G, Mausberg AK, Müller JI, Lehmann HC, Löber S, Gmeiner P, Hartung HP, Stüve O, Korth C, Kieseier BC (2011)

Publication Language: English

Publication Type: Journal article, Original article

Publication year: 2011

Journal

PLoS ONE Public Library of Science

Original Authors: Meyer zu Horste G., Mausberg A.K., Muller J.I., Lehmann H.C., Lober S., Gmeiner P., Hartung H.-P., Stuve O., Korth C., Kieseier B.C.

Publisher: Public Library of Science

Book Volume: 6

Article Number: e21223

Journal Issue: 6

DOI: 10.1371/journal.pone.0021223

Abstract

Activation of inflammatory cells is central to the pathogenesis of autoimmune demyelinating diseases of the peripheral nervous system. The novel chimeric compound quinpramine-generated from imipramine and quinacrine-redistributes cholesterol rich membrane domains to intracellular compartments. We studied the immunological and clinical effects of quinpramine in myelin homogenate induced Lewis rat experimental autoimmune neuritis (EAN), a model system for acute human inflammatory neuropathies, such as the Guillain-Barré syndrome. EAN animals develop paresis of all limbs due to autoimmune inflammation of peripheral nerves. Quinpramine treatment ameliorated clinical disease severity of EAN and infiltration of macrophages into peripheral nerves. It reduced expression of MHC class II molecules on antigen presenting cells and antigen specific T cell proliferation both in vitro and in vivo. Quinpramine exerted its anti-proliferatory effect on antigen presenting cells, but not on responder T cells. Our data suggest that quinpramine represents a candidate pharmaceutical for inflammatory neuropathies. © 2011 Meyer zu Hörste et al.

Authors with CRIS profile

Stefan Löber Lehrstuhl für Pharmazeutische Chemie Peter Gmeiner Lehrstuhl für Pharmazeutische Chemie

Additional Organisation(s)

Emil-Fischer-Zentrum (Emil Fischer Center)

Involved external institutions

Heinrich-Heine-Universität Düsseldorf DE Germany (DE) University of Texas Southwestern Medical Center (UT Southwestern) US United States (USA) (US)

How to cite

APA:

Meyer zu Hörste, G., Mausberg, A.K., Müller, J.I., Lehmann, H.C., Löber, S., Gmeiner, P.,... Kieseier, B.C. (2011). Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules. PLoS ONE, 6(6). https://doi.org/10.1371/journal.pone.0021223

MLA:

Meyer zu Hörste, Gerd, et al. "Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules." PLoS ONE 6.6 (2011).

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