Numerical Solution for 5-Layer Laminate Technique to determine Saturation Solubility of a Drug in a Thin Film of Pressure Sensitive Adhesive

Journal article
(Original article)


Publication Details

Author(s): Bänsch E, Lee G, Reismann S
Journal: Pharmaceutical Development and Technology
Publisher: Informa Healthcare
Publication year: 2014
Volume: 19
Journal issue: 5
Pages range: 634-640
ISSN: 1083-7450


Abstract


A numerical solution of the one-dimensional diffusion equation is presented to describe the 5-layer laminate technique for estimating the saturation solubility of a drug in a thin polymer film. The boundary and initial conditions encompass a donor layer, a separating membrane, and an acceptor layer. Alteration of the drug's partition coefficient between donor and separating membrane has little influence on drug accumulation with the acceptor. The diffusivity in the separating membrane should be high to promote a short experimental time to achieve saturation equilibrium in the acceptor layer. The essential parameter to give rapid equilibrium is the thickness of the acceptor polymer film. For values of diffusivity typical for drugs of molecular weight around 500 an acceptor layer thickness of 10 μm-20 μm is required to achieve equilibrium within less than 10 d. These simulations allow the selection of suitable experimental conditions to make the 5-layer laminate technique a viable method for routine use. © 2014 Informa Healthcare USA, Inc.



FAU Authors / FAU Editors

Bänsch, Eberhard Prof. Dr.
Lehrstuhl für Angewandte Mathematik (Wissenschaftliches Rechnen)
Lee, Geoffrey Prof.
Lehrstuhl für Pharmazeutische Technologie


How to cite

APA:
Bänsch, E., Lee, G., & Reismann, S. (2014). Numerical Solution for 5-Layer Laminate Technique to determine Saturation Solubility of a Drug in a Thin Film of Pressure Sensitive Adhesive. Pharmaceutical Development and Technology, 19(5), 634-640. https://dx.doi.org/10.3109/10837450.2013.819016

MLA:
Bänsch, Eberhard, Geoffrey Lee, and Simone Reismann. "Numerical Solution for 5-Layer Laminate Technique to determine Saturation Solubility of a Drug in a Thin Film of Pressure Sensitive Adhesive." Pharmaceutical Development and Technology 19.5 (2014): 634-640.

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Last updated on 2019-21-07 at 08:06