T2* mapping for articular cartilage assessment: principles, current applications, and future prospects
Hesper T, Hosalkar HS, Bittersohl D, Welsch G, Krauspe R, Zilkens C, Bittersohl B (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Publisher: Springer Verlag (Germany)
Book Volume: 43
Pages Range: 1429-45
Journal Issue: 10
DOI: 10.1007/s00256-014-1852-3
Abstract
With advances in joint preservation surgery that are intended to alter the course of osteoarthritis by early intervention, accurate and reliable assessment of the cartilage status is critical. Biochemically sensitive MRI techniques can add robust biomarkers for disease onset and progression, and therefore, could be meaningful assessment tools for the diagnosis and follow-up of cartilage abnormalities. T2* mapping could be a good alternative because it would combine the benefits of biochemical cartilage evaluation with remarkable features including short imaging time and the ability of high-resolution three-dimensional cartilage evaluation-without the need for contrast media administration or special hardware. Several in vitro and in vivo studies, which have elaborated on the potential of cartilage T2* assessment in various cartilage disease patterns and grades of degeneration, have been reported. However, much remains to be understood and certain unresolved questions have become apparent with these studies that are crucial to the further application of this technique. This review summarizes the principles of the technique and current applications of T2* mapping for articular cartilage assessment. Limitations of recent studies are discussed and the potential implications for patient care are presented.
Involved external institutions
Germany (DE)How to cite
APA:
Hesper, T., Hosalkar, H.S., Bittersohl, D., Welsch, G., Krauspe, R., Zilkens, C., & Bittersohl, B. (2014). T2* mapping for articular cartilage assessment: principles, current applications, and future prospects. Skeletal Radiology, 43(10), 1429-45. https://doi.org/10.1007/s00256-014-1852-3
MLA:
Hesper, Tobias, et al. "T2* mapping for articular cartilage assessment: principles, current applications, and future prospects." Skeletal Radiology 43.10 (2014): 1429-45.
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