Multifunctional bioactive glass scaffolds coated with layers of poly(d,l-lactide-co-glycolide) and poly(n-isopropylacrylamide-co-acrylic acid) microgels loaded with vancomycin

Olalde B, Garmendia N, Saez-Martinez V, Argarate N, Nooeaid P, Morin F, Boccaccini AR (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Materials Science and Engineering C Elsevier

Publisher: Elsevier

Pages Range: 3760-3767

Journal Issue: 33(7)

DOI: 10.1016/j.msec.2013.05.002

Abstract

A new family of multifunctional scaffolds, incorporating selected biopolymer coatings on basic Bioglass® derived foams has been developed. The polymer coatings were investigated as carrier of vancomycin which is a suitable drug to impart antibiotic function to the scaffolds. It has been proved that coating with PLGA (poly(lactic-co-glycolic acid)) with dispersed vancomycin-loaded microgels provides a rapid delivery of drug to give antibacterial effects at the wound site and a further sustained release to aid mid to long-term healing. Furthermore, the microgels also improved the bioactivity of the scaffolds by acting as nucleation sites for the formation of HA crystals in simulated body fluid. © 2013 Elsevier B.V.

Authors with CRIS profile

Patcharakamon Nooeaid Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Foundation for the Research and Development of Nanotechnology (FiDeNa) ES Spain (ES) Tecnalia Research & Innovation Foundation ES Spain (ES)

How to cite

APA:

Olalde, B., Garmendia, N., Saez-Martinez, V., Argarate, N., Nooeaid, P., Morin, F., & Boccaccini, A.R. (2013). Multifunctional bioactive glass scaffolds coated with layers of poly(d,l-lactide-co-glycolide) and poly(n-isopropylacrylamide-co-acrylic acid) microgels loaded with vancomycin. Materials Science and Engineering C, 33(7), 3760-3767. https://dx.doi.org/10.1016/j.msec.2013.05.002

MLA:

Olalde, B., et al. "Multifunctional bioactive glass scaffolds coated with layers of poly(d,l-lactide-co-glycolide) and poly(n-isopropylacrylamide-co-acrylic acid) microgels loaded with vancomycin." Materials Science and Engineering C 33(7) (2013): 3760-3767.

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