The homopolymer poly(3-hydroxyoctanoate) as a matrix material for soft tissue engineering

Rai R, Boccaccini AR, Knowles JC, Mordon N, Salih V, Locke IC, Moshrefi-Torbati M, Keshavarz T, Roy I (2011)

Publication Type: Journal article

Publication year: 2011

Journal

Journal of Applied Polymer Science Wiley

Publisher: Wiley-Blackwell

Pages Range: 3606-3617

Journal Issue: 122

DOI: 10.1002/app.34772

Abstract

The homopolymer poly(3-hydroxyoctanoate), produced from Pseudomonas mendocina with octanoate as a carbon feed, was studied as a potential biomaterial for soft tissue engineering, that is, as a cardiac patch and as matrices for skin tissue engineering. The polymer was fabricated into neat solvent-cast films of 5 and 10 wt %. Microstructural studies revealed the films as having a smooth surface topography with a root mean square value of 0.238 μm. The films also possessed moderate hydrophilicity when compared to other monomers of the polyhydroxyalkanoate family. Stress-strain curves of the films obtained was typical of that of elastomeric polymers. This elastomeric and flexible nature of the films makes them promising candidates for the proposed applications. Biocompatibility studies with the human adult low calcium temperature keratinocytes (HaCaT) keratinocyte cell line showed that the films were able to support the attachment, differentiation, and maturation of the HaCaT cells. In vitro degradation studies over a period of 4 months showed that the water absorption and weight loss increased progressively with time for the films. The films underwent hydrolytic degradation initiated on the surface and also showed an aging effect. © 2011 Wiley Periodicals, Inc.

Authors with CRIS profile

Ranjana Rai Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

University College London (UCL) GB United Kingdom (GB) University of Westminster GB United Kingdom (GB) University of Southampton GB United Kingdom (GB)

How to cite

APA:

Rai, R., Boccaccini, A.R., Knowles, J.C., Mordon, N., Salih, V., Locke, I.C.,... Roy, I. (2011). The homopolymer poly(3-hydroxyoctanoate) as a matrix material for soft tissue engineering. Journal of Applied Polymer Science, 122, 3606-3617. https://dx.doi.org/10.1002/app.34772

MLA:

Rai, Ranjana, et al. "The homopolymer poly(3-hydroxyoctanoate) as a matrix material for soft tissue engineering." Journal of Applied Polymer Science 122 (2011): 3606-3617.

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