Proline derived spirobarbiturates as highly effective β-turn mimetics incorporating polar and functionalizable constraint elements

Lomlim L, Einsiedel J, Heinemann FW, Meyer K, Gmeiner P (2008)

Publication Type: Journal article, Original article

Publication year: 2008

Journal

Original Authors: Lomlim L., Einsiedel J., Heinemann F.W., Meyer K., Gmeiner P.

Publisher: American Chemical Society

Book Volume: 73

Pages Range: 3608-3611

Journal Issue: 9

DOI: 10.1021/jo702573z

Abstract

(Chemical Equation Presented) A practical and efficient synthesis of spirobarbiturates of type III is reported when NH acidity of the imide function of the hydrophilic linker element allowed the introduction of different substituents. Structural characterization, which was based on both X-ray crystallography and spectroscopic investigations, indicated type II β-turn formation. Introduction of the molecular scaffold into solid phase peptide synthesis gave rise to spirocyclic neuropeptide analogs. © 2008 American Chemical Society.

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How to cite

APA:

Lomlim, L., Einsiedel, J., Heinemann, F.W., Meyer, K., & Gmeiner, P. (2008). Proline derived spirobarbiturates as highly effective β-turn mimetics incorporating polar and functionalizable constraint elements. Journal of Organic Chemistry, 73(9), 3608-3611. https://dx.doi.org/10.1021/jo702573z

MLA:

Lomlim, Luelak, et al. "Proline derived spirobarbiturates as highly effective β-turn mimetics incorporating polar and functionalizable constraint elements." Journal of Organic Chemistry 73.9 (2008): 3608-3611.

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