Hormone Therapy and its Effect on the Prognosis in Breast Cancer Patients

Rauh C, Schuetz F, Rack B, Stickeler E, Klar M, Orlowska-Volk M, Windfuhr-Blum M, Heil J, Rom J, Sohn C, Andergassen U, Jueckstock J, Fehm T, Löhberg C, Hein A, Schulz-Wendtland R, Hartmann A, Beckmann M, Janni W, Fasching P, Häberle L (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Geburtshilfe und Frauenheilkunde Georg Thieme Verlag

Publisher: Georg Thieme Verlag

Book Volume: 75

Pages Range: 588-596

Journal Issue: 6

DOI: 10.1055/s-0035-1546149

Abstract

Introduction: Use of hormone therapy (HT) has declined dramatically in recent years. Some studies have reported that HT use before a diagnosis of breast cancer (BC) may be a prognostic factor in postmenopausal patients. This study aimed to examine the prognostic relevance of HT use before BC diagnosis. Methods: Four BC cohort studies in Germany were pooled, and 4492 postmenopausal patients with HT use data were identified. Patient data and tumor characteristics were compared between users and nonusers, along with overall survival (OS), distant metastasis-free survival (DMFS), and local recurrence-free survival (LRFS). Cox proportional hazards models were stratified by study center and adjusted for age at diagnosis, tumor stage, grading, nodal status, and hormone receptors. Results: Women with HT use before the diagnosis of BC were more likely to have a lower tumor stage, to be estrogen receptor-negative, and to have a lower grading. With regard to prognosis there were effects seen for OS, DMFS and LRFS, specifically in the subgroup of women with a positive hormone receptor. In these subgroups, BC patients had a better prognosis with previous HT use. Conclusions: HT use before a diagnosis of BC is associated with a more favorable prognosis in women with a positive hormone receptor status. It may be recommended that the prognostic factor HT should be documented and analyzed as a confounder for prognosis in studies of postmenopausal hormone-responsive breast cancers.

Authors with CRIS profile

Christian Löhberg Department of Obstetrics and Gynaecology Alexander Hein Department of Obstetrics and Gynaecology Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Matthias Beckmann Lehrstuhl für Geburtshilfe und Frauenheilkunde Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe

Involved external institutions

Universitätsklinikum Ulm DE Germany (DE) Universitätsklinikum Heidelberg DE Germany (DE) Ludwig-Maximilians-Universität (LMU) DE Germany (DE) Albert-Ludwigs-Universität Freiburg DE Germany (DE) Universitätsklinikum Düsseldorf DE Germany (DE)

How to cite

APA:

Rauh, C., Schuetz, F., Rack, B., Stickeler, E., Klar, M., Orlowska-Volk, M.,... Häberle, L. (2015). Hormone Therapy and its Effect on the Prognosis in Breast Cancer Patients. Geburtshilfe und Frauenheilkunde, 75(6), 588-596. https://doi.org/10.1055/s-0035-1546149

MLA:

Rauh, C., et al. "Hormone Therapy and its Effect on the Prognosis in Breast Cancer Patients." Geburtshilfe und Frauenheilkunde 75.6 (2015): 588-596.

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