Development of curative therapies for Ewing sarcomas by interdisciplinary cooperative groups in Europe

Boelling T, Braun-Munzinger G, Burdach S, Calaminus G, Craft A, Delattre O, Deley MCL, Dirksen U, Dockhorn-Dworniczak B, Dunst J, Engel S, Faldum A, Froehlich B, Gadner H, Goebel U, Gosheger G, Hardes J, Hawkins DS, Hjorth L, Hoffmann C, Kovar H, Kruseova J, Ladenstein R, Leuschner I, Lewis IJ, Oberlin O, Paulussen M, Potratz J, Ranft A, Roessig C, Ruebe C, Sauer R, Schober O, Schuck A, Timmermann B, Tirode F, Van Den Berg H, Van Valen F, Vieth V, Willich N, Winkelmann W, Whelan J, Womer RB (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Publisher: Georg Thieme Verlag

Book Volume: 227

Pages Range: 108-15

Journal Issue: 3

DOI: 10.1055/s-0035-1545263

Abstract

Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area in which interdisciplinary and international cooperation is essential for future progress. This article reviews current state-of-the art therapy, with a focus on trials performed in Europe, and summarizes novel strategies to further advance both the cure rates and quality of survival.

Involved external institutions

Zentrum für Strahlentherapie Rheine-Osnabrück Germany (DE) Universitätsklinikum Münster Germany (DE) Technische Universität München (TUM) Germany (DE) Royal Victoria Infirmary United Kingdom (GB) National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM) France (FR) University of Paris 11 - Paris-Sud / Université Paris XI Paris-Sud France (FR) Klinikum Kempten Germany (DE) Universität zu Lübeck Germany (DE) Westfälische Wilhelms-Universität (WWU) Münster Germany (DE) St. Anna Kinderkrebsforschung Austria (AT) Heinrich-Heine-Universität Düsseldorf Germany (DE) University of Washington United States (USA) (US) Lund University / Lunds universitet Sweden (SE) Univerzita Karlova v Praze / Charles University in Prague Czech Republic (CZ) Christian-Albrechts-Universität zu Kiel Germany (DE) Alder Hey Children's Hospital United Kingdom (GB) Institut Gustave-Roussy France (FR) Universität Witten/Herdecke Germany (DE) Universität des Saarlandes (UdS) Germany (DE) Universitätsklinikum Essen Germany (DE) University of Amsterdam Netherlands (NL) King's College Hospital (KCH) United Kingdom (GB) University of Pennsylvania United States (USA) (US)

How to cite

APA:

Boelling, T., Braun-Munzinger, G., Burdach, S., Calaminus, G., Craft, A., Delattre, O.,... Womer, R.B. (2015). Development of curative therapies for Ewing sarcomas by interdisciplinary cooperative groups in Europe. Klinische Pädiatrie, 227(3), 108-15. https://dx.doi.org/10.1055/s-0035-1545263

MLA:

Boelling, T., et al. "Development of curative therapies for Ewing sarcomas by interdisciplinary cooperative groups in Europe." Klinische Pädiatrie 227.3 (2015): 108-15.

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