Evaluation of plasma trace element and mineral status in children and adolescents with phenylketonuria using data from inductively-coupled-plasma atomic emission and mass spectrometric analysis

Knerr I, Blessing H, Seyferth S, Watling RJ, Chaudhri A (2013)

Publication Type: Journal article, Original article

Publication year: 2013

Journal

Annals of Nutrition and Metabolism Karger

Original Authors: Knerr I., Blessing H., Seyferth S., Watling R., Chaudhri M.

Publisher: Karger

Book Volume: 63

Pages Range: 168-173

Journal Issue: null

DOI: 10.1159/000354869

Abstract

Background: Phenylketonuria (PKU) is caused by a severe phenylalanine hydroxylase deficiency; the mainstay of treatment is a low-phenylalanine diet. A diet which is so restrictive is associated with a risk of nutritional deficiencies. We investigated plasma concentrations for 46 elements, including minerals and trace elements. Methods: We enrolled 20 children and adolescents with PKU and 20 matched controls. Multi-elementary quantification was carried out by solution-based inductively coupled plasma atomic emission spectroscopy (ICP-AES) and ICP mass spectrometry (ICP-MS). Results: With the exception of manganese and aluminium, no significant differences were found for element levels between PKU patients and controls. As a trend, manganese levels were lower in PKU patients than in control subjects (p < 0.05) but were within the reference range. There was a positive linear relationship between manganese and tyrosine levels in subjects with PKU (r = 0.2295, p < 0.05). If detectable, potentially toxic elements were only identified in ultra-trace quantities in plasma samples of either group; aluminium levels were found to be slightly higher in PKU subjects than in controls (p < 0.01). Conclusion: The combination of ICP-AES and ICP-MS data is a useful diagnostic tool for element quantification at a high analytical rate and for monitoring bio-element status, e.g. in patients on a restrictive diet. Copyright © 2013 S. Karger AG, Basel.

Authors with CRIS profile

Stefan Seyferth Lehrstuhl für Pharmazeutische Technologie und Biopharmazie Mohammad Anwar Chaudhri Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Temple Street Children's University Hospital / Children's Health Ireland (CHI) IE Ireland (IE) University of Western Australia (UWA) AU Australia (AU)

How to cite

APA:

Knerr, I., Blessing, H., Seyferth, S., Watling, R.J., & Chaudhri, A. (2013). Evaluation of plasma trace element and mineral status in children and adolescents with phenylketonuria using data from inductively-coupled-plasma atomic emission and mass spectrometric analysis. Annals of Nutrition and Metabolism, 63(null), 168-173. https://doi.org/10.1159/000354869

MLA:

Knerr, Ina, et al. "Evaluation of plasma trace element and mineral status in children and adolescents with phenylketonuria using data from inductively-coupled-plasma atomic emission and mass spectrometric analysis." Annals of Nutrition and Metabolism 63.null (2013): 168-173.

BibTeX: Download