Romeis S, Hoppe A, Detsch R, Boccaccini AR, Schmidt J, Peukert W (2015)
Publication Status: Published
Publication Type: Journal article
Publication year: 2015
Publisher: Elsevier Ltd
Book Volume: 102
Pages Range: 534-541
DOI: 10.1016/j.proeng.2015.01.116
45S5 Bioglass® (45S5BG - 45 wt.% SiO, 24.5 wt.% CaO, 24.5 wt.% NaO and 6 wt.% PO glass forming system) is a frequently applied type A bioactive material, forming an inherent bond to bone and soft tissue. Recent studies for nanometer sized bioactive glasses (nBG) have indicated their great potential for several biomedical applications. It is recognized that cost-efficient processing routes are required for the development of submicron bioactive glasses, given the advantages associated with the nanoscale. In this study, the potential of top-down processing of 45S5BG by wet comminution in a stirred media mill is investigated and the key importance of the used solvents is revealed: whereas bioactive submicron particles can be produced in organic solvents, as shown exemplarily for n-pentanol, bioactivity is lost after processing in water. Analysis of the elemental constituents in the solid phase by ICP-OES indicates enhanced dissolution during processing in water, i.e. The glass composition is changing during processing. In n-pentanol the overall composition and structure is maintained and only the formation of surface carbonates is observed; flake-like particles are obtained. As a marker for bioactivity in vitro hydroxycarbonate apatite formation as determined by FTIR is used; biocompatibility is addressed by in vitro incubation with osteoblast like MG-63 cells. All-together, we propose wet comminution under controlled conditions as an appropriate technique to produce submicrometer bioactive glass particles with enhanced bioactivity.
APA:
Romeis, S., Hoppe, A., Detsch, R., Boccaccini, A.R., Schmidt, J., & Peukert, W. (2015). Top-down processing of submicron 45S5 Bioglass® for enhanced in vitro bioactivity and biocompatibility. Procedia Engineering, 102, 534-541. https://dx.doi.org/10.1016/j.proeng.2015.01.116
MLA:
Romeis, Stefan, et al. "Top-down processing of submicron 45S5 Bioglass® for enhanced in vitro bioactivity and biocompatibility." Procedia Engineering 102 (2015): 534-541.
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