Biodegradable poly(glycerol sebacate)/poly(3-hydroxybutyrate)-TiO2 nanocomposites: fabrication and characterisation

Journal article
(Original article)

Publication Details

Author(s): Roether J, Rai R, Wolf R, Tallawi M, Boccaccini AR
Journal: Materials Science and Technology
Publisher: Maney Publishing
Publication year: 2014
Volume: 30
Journal issue: 5
Pages range: 574-581
ISSN: 0267-0836


Novel Nanocomposite films containing TiO2 nanoparticles incorporated in blend matrices of biocompatible and bioresorbable polymers, namely poly(glycerol sebacate) (PGS) and poly(3-hydroxybutyrate) P(3HB), were developed. The samples were fabricated via a sequential step of solvent casting followed by cross-linking. PGS/P(3HB) blends (controls) were fabricated in two different ratios, i.e. 7 : 1 and 8 : 1. Varying amounts of TiO2 nanoparticles (1 and 2 vol.-%) were incorporated into the matrices. SEM studies revealed that the TiO2 particles were distributed both within the matrix and on the surface of the films thus imparting surface nanotopography and increasing the surface roughness. These microstructural features combined with the cumulative effect of blending of the two polymeric systems influenced the wettability, chemical and mechanical properties of the films. In vitro degradation of the fabricated matrices in PBS medium over a 30 day period confirmed that the composites undergo weight loss and mechanical, chemical and surface topography changes. The nanocomposites constitute model biodegradable organic-inorganic systems suitable for tissue engineering applications.

FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Rai, Ranjana
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Roether, Judith
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Tallawi, Marwa
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

How to cite

Roether, J., Rai, R., Wolf, R., Tallawi, M., & Boccaccini, A.R. (2014). Biodegradable poly(glycerol sebacate)/poly(3-hydroxybutyrate)-TiO2 nanocomposites: fabrication and characterisation. Materials Science and Technology, 30(5), 574-581.

Roether, Judith, et al. "Biodegradable poly(glycerol sebacate)/poly(3-hydroxybutyrate)-TiO2 nanocomposites: fabrication and characterisation." Materials Science and Technology 30.5 (2014): 574-581.


Last updated on 2018-07-08 at 17:08