Synthetic Lipoteichoic Acid Glycans Are Potential Vaccine Candidates to Protect from Clostridium difficile Infections

Broecker F, Martin CE, Wegner E, Mattner J, Baek JY, Pereira CL, Anish C, Seeberger PH (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Cell Chemical Biology Elsevier Science

Book Volume: 23

Pages Range: 1014-1022

Journal Issue: 8

DOI: 10.1016/j.chembiol.2016.07.009

Abstract

Infections with Clostridium difficile increasingly cause morbidity and mortality worldwide. Bacterial surface glycans including lipoteichoic acid (LTA) were identified as auspicious vaccine antigens to prevent colonization. Here, we report on the potential of synthetic LTA glycans as vaccine candidates. We identified LTA-specific antibodies in the blood of C. difficile patients. Therefore, we evaluated the immunogenicity of a semi-synthetic LTA-CRM197 glycoconjugate. The conjugate elicited LTA-specific antibodies in mice that recognized natural LTA epitopes on the surface of C. difficile bacteria and inhibited intestinal colonization of C. difficile in mice in vivo. Our findings underscore the promise of synthetic LTA glycans as C. difficile vaccine candidates.

Authors with CRIS profile

Jochen Mattner Professur für Medizinische Mikrobiologie und Infektionsimmunologie

Involved external institutions

Max-Planck-Institut für Kolloid- und Grenzflächenforschung / Max Planck Institute of Colloids and Interfaces DE Germany (DE)

How to cite

APA:

Broecker, F., Martin, C.E., Wegner, E., Mattner, J., Baek, J.Y., Pereira, C.L.,... Seeberger, P.H. (2016). Synthetic Lipoteichoic Acid Glycans Are Potential Vaccine Candidates to Protect from Clostridium difficile Infections. Cell Chemical Biology, 23(8), 1014-1022. https://doi.org/10.1016/j.chembiol.2016.07.009

MLA:

Broecker, Felix, et al. "Synthetic Lipoteichoic Acid Glycans Are Potential Vaccine Candidates to Protect from Clostridium difficile Infections." Cell Chemical Biology 23.8 (2016): 1014-1022.

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